32223-70-4Relevant academic research and scientific papers
Oxime Carbamate-Discovery of a series of novel FAAH inhibitors
Sit,Conway, Charles M.,Xie, Kai,Bertekap, Robert,Bourin, Clotilde,Burris, Kevin D.
supporting information; experimental part, p. 1272 - 1277 (2010/06/17)
A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of selected targets are discussed, along with inhibition kinetics and molecular modeling studies.1.
Using acetate anions to induce translational isomerization in a neutral urea-based molecular switch
Huang, Yi-Lin,Hung, Wei-Chung,Lai, Chien-Chen,Liu, Yi-Hung,Peng, Shie-Ming,Chiu, Sheng-Hsien
, p. 6629 - 6633 (2008/09/18)
Vying for urea: The translational isomerism of a neutral [2]rotaxane can be controlled in solution through the addition and removal of acetate anions. In the absence of acetate ions, the macrocyclic host recognizes a diphenylurea derivative; recognition of acetate ions by the urea-based station causes relocation of the macrocycle to another binding site (see picture). (Figure Presented).
Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas
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, (2008/06/13)
The compounds of this invention are novel imidoylureas having anthelmintic activity and imidoylthioureas having antifertility activity. They are prepared by the reaction of appropriate amidines with appropriate isocyanates or isothiocyanates.
