322398-96-9Relevant academic research and scientific papers
The synthesis of isomeric 4-prolinylamines and 4,4′-diprolinylamines
Yelin,Onoprienko,Kudelina,Miroshnikov
, p. 774 - 783 (2007/10/03)
Starting from the previously described tert-butyl esters of 4-epimeric N-benzyloxycarbonyl-4-hydroxyprolines and N-benzyloxycarbonyl-4-trans- and 4-cis-trifluoroacetaminoproline tert-butyl esters, the corresponding unprotected 4-aminoprolines and a number of their partially protected derivatives were synthesized via the intermediate 4-O-mesyl and 4-azide derivatives. The reductive animation of N-benzyloxycarbonyl-4-oxoproline tert-butyl ester with ammonium acetate led to N-benzyloxycarbonyl-4-cis-4′-cis- and 4-cis-4′-trans-diprolinylamines. The 1H NMR and CD spectra of the synthesized compounds are described.
