322428-87-5Relevant academic research and scientific papers
Synthesis of (-)-hennoxazole A: Integrating batch and flow chemistry methods
Fernández, Amadeo,Levine, Zebulon G.,Baumann, Marcus,Sulzer-Mossé, Sarah,Sparr, Christof,Schl?ger, Sabrina,Metzger, Albrecht,Baxendale, Ian R.,Ley, Steven V.
, p. 514 - 518 (2013/04/10)
A new total synthesis of (-)-hennoxazole A is reported. The synthetic approach is based on the preparation of three similarly sized fragments resulting in a fast and convergent assembly of the natural product. The three key reactions of the synthesis include a highly stereoselective 1,5-anti aldol coupling, a gold-catalyzed alkoxycyclization reaction, and a stereocontrolled diene cross-metathesis. The synthesis involves integrated batch and flow chemistry methods leading to the natural product in 16 steps longest linear sequence and 2.8% overall yield. Georg Thieme Verlag Stuttgart · New York.
Total synthesis of (-)-hennoxazole A
Yokokawa, Fumiaki,Asano, Toshinobu,Shioiri, Takayuki
, p. 6311 - 6327 (2007/10/03)
The antiviral marine natural product (-)-hennoxazole A was efficiently synthesized by a convergent approach. The stereoselective synthesis of the functionalized tetrahydropyran fragment was accomplished by the Mukaiyama aldol reaction, chelation-controlle
Total synthesis of the antiviral marine natural product (-)-hennoxazole A.
Yokokawa,Asano,Shioiri
, p. 4169 - 4172 (2007/10/03)
[structure:see text] The marine natural product hennoxazole A was synthesized by a convergent approach. The diastereoselective Mukaiyama aldol reaction with beta-alkoxy aldehyde was used to construct the tetrahydropyran segment, and the preparation of the
