32272-18-7

Upstream product

• 32274-70-7 2,2'-dihydroxy-4'-methoxy-trans-chalcone 
• 77-78-1 dimethyl sulfate 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 135-02-4 ortho-anisaldehyde 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1804-91-7 2'-benzyloxy-2,4'-dimethoxychalkone epoxide 
• 32272-17-6 7-methoxy-2-(2-methoxy-phenyl)-chroman-4-one 
• 1621-63-2 2'-benzyloxy-2,4'-dimethoxychalcone 
• 62536-78-1 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one 
• 77764-83-1 (Z)-6-methoxy-2-(2-methoxybenzylidene)benzofuran-3(2H)-one 
• 19725-40-7 7-methoxy-3-(2-methoxyphenyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives

A group of 3,5-diaryl-2-pyrazoline and hydrazone derivatives was prepared via the reaction of various chalcones with hydrazide compounds in ethanol. Twenty original compounds were synthesized. Ten of these original compounds have a pyrazoline structure, n

NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA

Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).

Synthesis and complete assignment of NMR data of 20 chalcones

Chalcones, intermediates in flavonoid biosynthesis, can exhibit antibacterial, antiproliferative, and anti-inflammatory properties. Chalcones contain two benzene rings and both hydroxylated and methoxylated analogs are frequently produced by hydroxylases and O-methyltransferases in plant biosynthetic pathways. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of 1H and 13C NMR spectra. Copyright

Synthesis and aromatase inhibitory activity of flavanones

Purpose. Aromatase inhibitors are known to prevent the conversion of androgens to estrogens and play a significant role in the treatment of estrogen dependent diseases such as breast cancer. Some flavonoids have been reported as potent aromatase inhibitors; therefore, in an effort to develop novel anti breast cancer agents, B ring substituted flavanones with a 7-methoxy group on A ring were synthesized and tested to assess their ability to inhibit aromatase activity and to determine the optimal B ring substitution pattern. Methods. A series of flavanones was prepared by cyclisation of 2′hydroxychalcones previously obtained by Claisen-Schmidt condensation and the aromatase inhibitory activity of these compounds was investigated using human placental microsomes and radiolabeled [1,2,6,7-3H]-androstenedione as substrate. Results. Almost all flavanones exhibited inhibitory effect on the aromatase activity but their potency was dependent on their B ring substitution pattern. Hydroxylation at position 3′ and/or 4′ enhanced the anti-aromatase activity; thus, 3′,4′-dihydroxy-7-methoxyflavanone was found to be twice more potent than aminoglutethimide, the first aromatase inhibitor clinically used. Conclusions. These results indicated that these flavanones could be considered as potential anti breast cancer agents through the inhibition of aromatase activity and allowed us to select some of these compounds as skeleton for the development of flavonoid structurally-related aromatase inhibitors.

Two Syntheses of 7,2'-Dimethoxyisoflavone

7,2'-Dimethoxyisoflavone (V) has been synthesised by two routes: (i) by direct oxidative rearrangement of 2'-hydroxy-2,4'-dimethoxychalkone; and (ii) by treatment of 2'-benzyloxy-2,4'-dimethoxychalkone epoxide (III) derivable from I, with BF3-etherate to