32279-81-5Relevant academic research and scientific papers
SYNTHESIS OF 2-SUBSTITUTED 3(2H)-ISOTHIAZOLONES FROM 2-SUBSTITUTED 5-AROYL-3(2H)-ISOTHIAZOLONES
Tsolomitis, Athanase,Sandris, Constantine
, p. 569 - 575 (2007/10/02)
2-Substituted 3(2H)-isothiazolones 3 have been prepared from 2-substituted 5-aroyl-3(2H)-isothiazolones 6, which are readily available from N-substituted 3-aroylpropionamides 5.The nucleophilic displacement on the 5-aroyl group was found to proceed easily and quantitatively when a benzene solution of compound 6 was stirred at room temperature either with 10percent sodium hydroxide solution or with solid sodium hydroxide.
