32281-01-9

Basic information

• Product Name: 4-Hydroxy-3-methylthiophenol
• Synonyms: 4-MERCAPTO-2-METHYL-PHENOL;4-HYDROXY-3-METHYL THIOPHENOL;4-HYDROXY-3-METHYL THIOPHENOL,98+%;Phenol,4-mercapto-2-methyl-;3-Methyl-4-hydroxythiophenol;4-Mercapto-O-cresol;4-Hydroxy-3-methylth;2-Methyl-4-sulfanylphenol
• CAS NO: 32281-01-9
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.2
• Product Categories: Multisubstituted Benzene;Phenol&Thiophenol&Mercaptan;Phenoles and thiophenoles;Drug Intermediates;Aromatics;Sulfur & Selenium Compounds
• Mol File: 32281-01-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 265.1°Cat760mmHg
• Flash Point: 114.1°C
• Appearance: /
• Density: 1.2g/cm³
• Vapor Pressure: 0.0057mmHg at 25°C
• Refractive Index: 1.622
• Solubility: Chloroform
• CAS DataBase Reference: 4-Hydroxy-3-methylthiophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-3-methylthiophenol(32281-01-9)
• EPA Substance Registry System: 4-Hydroxy-3-methylthiophenol(32281-01-9)

Safety Data

• Hazardous Substances Data: 32281-01-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

InChI:InChI=1/C7H8OS/c1-5-4-6(9)2-3-7(5)8/h2-4,8-9H,1H3

Upstream product

• 5306-98-9 5-chloro-2-methyl-phenol 
• 99070-97-0 O-Ethoxycarbonyl-2-methyl-phenol-sulfonsaeure-⁽⁴⁾-chlorid 
• 3774-53-6 2-methyl-4-thiocyanato-phenol 
• 95-48-7 ortho-cresol 
• 2362-12-1 4-Bromo-2-methylphenol 

Downstream Products

• 1268500-84-0 ethyl 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate 
• 1268500-86-2 ethyl 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate 
• 1268500-53-3 2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid 
• 1026868-55-2 2-methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid 
• 1030367-79-3 2-methyl-4-(((4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)methyl)thio)phenol 
• 1207268-95-8 ethyl 2,2-dimethyl-2-(3-methyl-4-(1-(2-(4-n-butyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 
• 1207268-90-3 methyl 2-methyl-2-(2-methyl-4-(1-(4-methyl-5-oxo-1-(4-trifluoromethylphenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzylthio)phenoxy)acetate 
• 1207269-28-0 C₂₄H₂₀F₃N₃O₂S 
• 1207268-93-6 ethyl 2,2-dimethyl-2-(3-methyl-4-(1-(2-(4-methyl-5-oxo-1-(4-trifluoromethylphenyl)-4,5-dihydrogen-1H-1,2,4.triazolyl))-benzylthio)-phenoxy)-acetate 
• 1207268-81-2 ethyl 2-(2-methyl-4-(1-(3-(4-methyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 
• 949018-92-2 ethyl 2-(3-methyl-4-hydroxy)-phenylthio-acetate 
• 1207269-27-9 C₄₈H₃₈F₆N₆O₄S₂ 
• 1207269-30-4 C₂₄H₂₀F₃N₃O₂S 
• 1207268-92-5 ethyl 2,2-dimethyl-2-(3-methyl-4-(1-(3-(4-methyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzyloxy)-phenylthio)-acetate 

Relevant articles and documents

A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor δ through in situ protection of the phenol group by reaction with a Grignard reagent

A new synthesis of an agonist for the peroxisome proliferator-activated receptor δ (PPARδ) GW501516 as a potential antiobesity drug is described. The synthetic route involves the in situ protection of the phenol group with a Grignard reagent and a regio-controlled one-pot reaction for the formation of a sulfide bond as the key step. Starting from commercially available 4-iodo-2-methylphenol, this approach affords GW501516 with an overall yield of 87%.

COMPOUND WITH AGITATION EFFECT ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR. PROCESS FOR ITS PREPARATION AND USE THEREOF

The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype δ (PPARδ), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPARδ thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.

ARYL PYRIMIDINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof. Various substituents in the formula (I) are as defined in the specification. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I), the preparation method of compound of formula (I), and the use of the compound for the preparation of a medicament for treating and/or preventing human peroxisome proliferators activated receptor δ (hPPARδ) -associated diseases and risk factors.