32288-17-8Relevant academic research and scientific papers
Microwave induced synthesis of O,O-dialkyl dialkylpyrophosphonates under solvent free conditions: Markers of nerve agents
Kumar, Rajesh,Pardasani, Deepak,Mazumder, Avik,Dubey, Devendra K.,Gupta, Arvind K.
, p. 476 - 480 (2008)
This article describes a one pot, solvent free, microwave assisted synthesis of O,O-dialkyl dialkylpyrophosphonates (DADAPP) from O-alkyl alkylphosphonic chlorides 2a?j with 4-dimethylaminopyridine (DMAP) in the presence of water under microwave irradiation. The reaction takes place by the phosphonium salts, which are converted into the DADAPPs 4a?j. These DADAPPs are important markers of chemical warfare agents sarin, soman, and VX and their analogues. The method has several advantages over the conventional methods such as operational simplicity, high yield, and reduced reaction time. CSIRO 2008.
Reaction of VX and GD with gaseous ozone
Wagner, George W.,Bartram, Philip W.,Brickhouse, Mark D.,Connell, Theresa R.,Creasy, William R.,Henderson, Vikki D.,Hovanec, Joseph W.,Morrissey, Kevin M.,Stuff, John R.,Williams, Barry R.
, p. 1267 - 1272 (2007/10/03)
Attempts at decontaminating nerve agents VX {O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate} and GD (pinacolyl methylphosphonofluoridate) with gaseous ozone are described. VX reacts like a tertiary amine with oxidation occurring at carbons adjacent to the nitrogen. In this manner a variety of novel VX derivatives still possessing intact P-S bonds are generated, and as such, must be considered to retain formidable toxicity. The major product is O-ethyl S-[2-(isopropylamino)ethyl] methylphosphonothioate. No reaction of GD with ozone occurs under the conditions employed.
Phosphorylation of N-trimethylsilyllactams
Uryupin, A. B.,Rakhov, I. A.,Kolesova, V. A.,Petrovskii, P. V.,Mastryukova, T. A.,Kabachnik, M. I.
, p. 1556 - 1560 (2007/10/02)
Treatment of N-trimethylsilyllactams with phosphoryl chlorides results in mixtures of products, whose formation can be explained by competition between N- and O-phosphorylation. - Key words: N-trimethylsilyllactams, dual reactivity; N-phosphoryllactams, synthesis.
