32289-58-0 Usage
Description
PHMB is best known for its broad-spectrum antimicrobial and antifungal activity.?It is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY). PHMB is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Application
Polyhexanide?(polyhexamethylene biguanide, PHMB) is a?polymer?used as a?disinfectant?and?antiseptic. In?dermatological?use, it is spelled?polihexanide?(INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against?Pseudomonas aeruginosa,?Staphylococcus aureus?(also the?methicillin-resistant type,?MRSA),?Escherichia coli,?Candida albicans?(yeast),?Aspergillus brasiliensis?(mold),?vancomycin-resistant?enterococci, and?Klebsiella pneumoniae?(carbapenem-resistant?enterobacteriaceae).
Safety
On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA.
Chemical Properties
Different sources of media describe the Chemical Properties of 32289-58-0 differently. You can refer to the following data:
1. Colorless to pale yellow solution
2. Poly(hexamethylenebiguanide)
hydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection. This compound has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect. Although it is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.
Uses
Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes
Biological Activity
Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.
Check Digit Verification of cas no
The CAS Registry Mumber 32289-58-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,2,8 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 32289-58:
(7*3)+(6*2)+(5*2)+(4*8)+(3*9)+(2*5)+(1*8)=120
120 % 10 = 0
So 32289-58-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H40N10.ClH/c1-15(19)24-11-7-3-4-9-13-26-17(21)28-18(22)27-14-10-6-5-8-12-25-16(20)23-2;/h3-14H2,1-2H3,(H2,19,24)(H3,20,23,25)(H5,21,22,26,27,28);1H
