323178-30-9

Basic information

• Product Name: 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)
• Synonyms: 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)
• CAS NO: 323178-30-9
• Molecular Formula: C₁₄H₁₈N₂O₄S
• Molecular Weight: 310.37
• Mol File: 323178-30-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 465.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.272±0.06 g/cm3(Predicted)
• PKA: 11.11±0.20(Predicted)
• CAS DataBase Reference: 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)(323178-30-9)
• EPA Substance Registry System: 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)(323178-30-9)

Safety Data

• Hazardous Substances Data: 323178-30-9(Hazardous Substances Data)

Usage

General Description

The chemical "1,2,7-thiadiazepine-2(3H)-acetic acid, 6,7-dihydro-alpha-(phenylmethyl)-, methyl ester, 1,1-dioxide, (alphas)" is a complex organic compound with a 1,2,7-thiadiazepine core and a methyl ester and 1,1-dioxide functional groups. The alpha-phenylmethyl group is also attached to the thiadiazepine ring. Thiadiazepines are a class of heterocyclic compounds with a sulfur atom in the seven-membered diazepine ring. This particular compound may have potential pharmacological or biological activities, and its chemical structure suggests that it could be used in medicinal chemistry for synthesizing novel drug candidates or as a research tool in the study of thiadiazepine-containing compounds.

Upstream product

• 104-54-1 3-Phenylpropenol 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 106-95-6 allyl bromide 
• 323178-28-5 N,N'-bis(2-propenyl)-N-(tert-butoxycarbonylsulfonyl)-L-phenylalanine methyl ester 
• 139059-69-1 <(S)(+)> methyl -phenylalaninate 
• 323178-29-6 2-(2S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-7-tert-butyloxycarbonyl-2-yl)]-3-phenylpropionic acid methyl ester 

Relevant articles and documents

Ring-opening metathesis phase-trafficking (ROMpt) synthesis: multistep synthesis on soluble ROM supports.

The use of ring-opening metathesis (ROM) oligomers as soluble supports for a multistep reaction sequence is described. A Mitsunobu reaction followed by an in situ ROMP-mediated phase-trafficking purification is utilized to generate soluble ROM oligomers t

Ring-closing metathesis strategies to cyclic sulfamide peptidomimetics

Ring-closing metathesis (RCM) strategies toward the synthesis of a number of constrained sulfamides are discussed. This approach exploits the inherent chemistry of sulfamides and sulfonyl carbamates to generate both symmetric and unsymmetric cyclic sulfamides. Two strategies are revealed, one centers on the RCM reaction of allylated sulfamides 9a-e to generate the C2-symmetric cyclic sulfamides 4a-e in high yields. A second RCM strategy utilizes the known sulfonyl carbamate 15 to prepare unsymmetric cyclic sulfamides 16 and 6 in two four-step sequences. Overall, the routes described are applicable to the synthesis of a variety of constrained dipeptidal sulfamides representing novel peptidomimetic scaffolds. (C) 2000 Published by Elsevier Science Ltd.