323180-02-5Relevant articles and documents
Synthesis, chemical reactivity as michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents(1)
Zheng, Suqing,Santosh Laxmi,David, Emilie,Dinkova-Kostova, Albena T.,Shiavoni, Katherine H.,Ren, Yanqing,Zheng, Ying,Trevino, Isaac,Bumeister, Ronald,Ojima, Iwao,Wigley, W. Christian,Bliska, James B.,Mierke, Dale F.,Honda, Tadashi
, p. 4837 - 4846 (2012/07/03)
Novel monocyclic cyanoenones examined to date display unique features regarding chemical reactivity as Michael acceptors and biological potency. Remarkably, in some biological assays, the simple structure is more potent than pentacyclic triterpenoids (e.g