323186-85-2

Upstream product

• 110-62-3 pentanal 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 

Downstream Products

• 1039769-39-5 2-butyl-3-phenyl-4-(1',3'-butadien-2'-yl)-2,5-dihydrofuran 
• 1006719-52-3 2-butyl-3-phenyl-4-((Z)-3-phenyl-1,3-octadien-2-yl)-2,5-dihydrofuran 

Relevant academic research and scientific papers

PdI2-catalyzed coupling-cyclization reactions involving two different 2,3-allenols: An efficient synthesis of 4-(1′,3′-dien- 2′-yl)-2,5-dihydrofuran derivatives

Transition-metal-catalyzed dimeric coupling-cyclization reactions of two different 2,3-allenols afforded 4-(1′,3′-dien-2′-yl)-2,5- dihydrofuran derivatives 3. 2-Substituted 2,3-allenols 1 cyclized to form the 2,5-dihydrofuran ring, whereas the 2-unsubstit

Efficient synthesis of 4-(2′-alkenyl)-2,5-dihydrofurans and 5,6-dihydro-2H-pyrans via the Pd-catalyzed cyclizative coupling reaction of 2,3- or 3,4-allenols with allylic halides

In the absence of a base, palladium(II) catalysts, such as PdCl2, PdCl2(CH3CN)2, Pd(OAc)2, and [(π-C3H5)PdCl]2, can catalyze the cyclizative coupling reaction of 2,3- or 3,4-allenols with allylic halides in DMA at room temperature to provide 2,5-dihydrofurans and 5,6-dihydro-2H-pyrans, respectively, in moderate to good yields. Under similar reaction conditions, nonsubstituted 2,3-allenol 1s affords bimolecular cyclizative coupling product 5s as the major product. The scope of the reaction and its mechanism have been studied briefly. On the basis of the experimental results, the transformation was believed to proceed via a divalent palladium-catalyzed pathway.