32321-45-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(bromomethyl)-2-ethylpropane-1,3-diol is used as an anti-cancer agent for the treatment of cutaneous T-cell lymphoma (CTCL) and Kaposi's sarcoma. It functions by activating retinoid X receptors (RXRs), which promotes the differentiation and apoptosis of cancerous cells, thereby providing a therapeutic effect against these diseases.
Used in Neurodegenerative Disease Research:
2-(bromomethyl)-2-ethylpropane-1,3-diol is also being studied for its potential use in the treatment of Alzheimer's disease. It targets amyloid-beta accumulation, a hallmark of Alzheimer's, suggesting that it could have a role in managing or treating this condition.
Used in Formulation Development:
Bexarotene is available in both oral and topical formulations, indicating its versatility in pharmaceutical development. The different formulations allow for targeted delivery to the areas of the body where the therapeutic effect is required, enhancing the compound's efficacy and patient compliance.
Used in Management of Side Effects:
Although generally well-tolerated, bexarotene may cause side effects such as hypothyroidism, elevated triglycerides, and skin irritation. As such, it is also used in the context of medical management to monitor and mitigate these potential side effects, ensuring the safe use of the compound in treatment regimens.
Overall, 2-(bromomethyl)-2-ethylpropane-1,3-diol, or bexarotene, is a multifaceted compound with established uses in dermatology and oncology, and potential applications in neurology and other medical fields.

Upstream product

• 77-99-6 1,1,1-tri(hydroxymethyl)propane 
• 3047-32-3 3-ethyl-3-(hydroxymethyl)oxetane 

Downstream Products

• 872295-37-9 5-ethyl-5-bromomethyl-2,2-diphenyl-[1,3]dioxane 

Relevant academic research and scientific papers

METHOD FOR MAKING A POLYMER, A POLYMER ARTICLE, A BIODEVICE, AND CYCLIC CARBONATE

The present invention relates to a method for making a polymer wherein during ring opening polymerisation is incorporated into the polymer chain at least one cyclic (alkyl) carbonate monomer having the formula (1) wherein Y is optional and represents the residue of a sulfhydryl reacted group, X represents a functional group reactive with a sulfhydryl group, L = -[CH2]n with n = 0-10, or L =–[CH2]p-S- S-[CH2]q with p and q are 0-5 or L =–[PEG]-with PEG is a group that comprises a –[CH2CH2O]m-group with m = 1-200, and R2 is hydrogen, methyl or ethyl. Optionally a cyclic (alkyl) acryloyl carbonate, or other additional monomer may be used as comonomer. The polymer may be formed into a polymer article, such as a polymer film, such as a coating and modified and/or cross linked, to a polymer or polymer article obtainable, and to a biodevice, their use, and to the cyclic (alkyl)carbonates.

Synthesis and polymerization of alkyl halide-functional cyclic carbonates

To increase the diversity in functional aliphatic polycarbonates, a series of novel chloro- and bromo-functional six-membered cyclic carbonate monomers were synthesized. Despite asymmetry in the monomer functionalities, homopolymerization of the monomers afforded semicrystalline polycarbonates with a high tendency to crystallize from the melt and/or on precipitation from a THF solution. Melting points were found in the 90-105 °C or 120-155 °C range for polymers comprising methyl or ethyl moieties, respectively, in the backbone. The monomers were further copolymerized with trimethylene carbonate to form random copolymers. Even among some of these random copolymers elements of semicrystallinity were found as confirmed by melting endotherms in DSC. The results clearly show that the incorporation of alkyl halide functionalities in aliphatic polycarbonates may lead to materials with a high ability to form crystallites, even in random copolymers, likely driven by polar interactions due to the presence of the halide functionalities.

Cyclic diphosphonates

Phosphonate compounds of the formula STR1 wherein R is hydrogen or methyl, R1 is hydrogen, methyl or ethyl, and y is an integer from 0 to 2, are useful as flame retardants for thermoplastic polymers, especially linear thermoplastic polyesters.