32321-45-2

Basic information

• Product Name: 2-(bromomethyl)-2-ethylpropane-1,3-diol
• CAS NO: 32321-45-2
• Molecular Formula: C₆H₁₃BrO₂
• Molecular Weight: 197.0702
• Mol File: 32321-45-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 300.2°C at 760 mmHg
• Flash Point: 135.4°C
• Density: 1.45g/cm³
• Vapor Pressure: 0.000112mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: 2-(bromomethyl)-2-ethylpropane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-2-ethylpropane-1,3-diol(32321-45-2)
• EPA Substance Registry System: 2-(bromomethyl)-2-ethylpropane-1,3-diol(32321-45-2)

Safety Data

• Hazardous Substances Data: 32321-45-2(Hazardous Substances Data)

Usage

General Description

2-(bromomethyl)-2-ethylpropane-1,3-diol, also known as bexarotene, is a chemical compound with the molecular formula C10H20BrO2. It is a synthetic retinoid that is used to treat cutaneous T-cell lymphoma (CTCL) and Kaposi's sarcoma. Bexarotene works by activating retinoid X receptors (RXRs) and promoting the differentiation and apoptosis of cancerous cells. Additionally, it has been studied for its potential use in the treatment of Alzheimer's disease by targeting amyloid-beta accumulation. Bexarotene is available in oral and topical formulations and is generally well-tolerated, although it may cause side effects such as hypothyroidism, elevated triglycerides, and skin irritation. Overall, bexarotene is a promising therapeutic option for various skin diseases and may have potential applications in other medical conditions.

Upstream product

• 3047-32-3 3-ethyl-3-(hydroxymethyl)oxetane 
• 77-99-6 1,1,1-tri(hydroxymethyl)propane 

Downstream Products

• 872295-37-9 5-ethyl-5-bromomethyl-2,2-diphenyl-[1,3]dioxane 

Relevant articles and documents

METHOD FOR MAKING A POLYMER, A POLYMER ARTICLE, A BIODEVICE, AND CYCLIC CARBONATE

The present invention relates to a method for making a polymer wherein during ring opening polymerisation is incorporated into the polymer chain at least one cyclic (alkyl) carbonate monomer having the formula (1) wherein Y is optional and represents the residue of a sulfhydryl reacted group, X represents a functional group reactive with a sulfhydryl group, L = -[CH2]n with n = 0-10, or L =–[CH2]p-S- S-[CH2]q with p and q are 0-5 or L =–[PEG]-with PEG is a group that comprises a –[CH2CH2O]m-group with m = 1-200, and R2 is hydrogen, methyl or ethyl. Optionally a cyclic (alkyl) acryloyl carbonate, or other additional monomer may be used as comonomer. The polymer may be formed into a polymer article, such as a polymer film, such as a coating and modified and/or cross linked, to a polymer or polymer article obtainable, and to a biodevice, their use, and to the cyclic (alkyl)carbonates.

Cyclic diphosphonates

Phosphonate compounds of the formula STR1 wherein R is hydrogen or methyl, R1 is hydrogen, methyl or ethyl, and y is an integer from 0 to 2, are useful as flame retardants for thermoplastic polymers, especially linear thermoplastic polyesters.