32337-85-2

Usage

Uses

Used in Organic Synthesis:
6-bromo-2,3-dihydro-1H-inden-5-ol is used as a building block in organic synthesis for its unique molecular structure, which allows for the creation of various complex organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 6-bromo-2,3-dihydro-1H-inden-5-ol is used as a starting material for the development of new drugs, leveraging its chemical properties to design and synthesize novel therapeutic agents.
Used in Agrochemical Development:
6-bromo-2,3-dihydro-1H-inden-5-ol is utilized in the development of new agrochemicals, where its unique structure can contribute to the creation of innovative and effective products for agricultural applications.
Used in Materials Science:
In the field of materials science, 6-bromo-2,3-dihydro-1H-inden-5-ol is employed for the development of new materials, taking advantage of its molecular properties to engineer advanced materials with specific characteristics.
Overall, 6-bromo-2,3-dihydro-1H-inden-5-ol is a versatile compound with a wide range of applications across various industries, making it an essential tool for scientists and researchers in chemistry, medicine, and materials science.

Upstream product

• 1470-94-6 5-hydroxy-2,3-dihydro-1H-indene 

Downstream Products

• 100200-87-1 6-phenyl-5-indanol 
• 112275-12-4 3-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-8,9-dihydro-1H,7H-indeno[5,4-b][1,4]oxazin-2-one 
• 198201-98-8 1-[6-Phenylsulfanyl-5-(tetrahydro-pyran-2-yloxy)-indan-4-yl]-propan-2-one 
• 198201-97-7 2-(6-Phenylsulfanyl-indan-5-yloxy)-tetrahydro-pyran 
• 139515-86-9 6-bromo-4-nitro-2,3-dihydro-5-indanol 

Relevant academic research and scientific papers

The Versatility of the Aryne-Imine-Aryne Coupling for the -Synthesis of Acridinium Photocatalysts

The increasing use of acridinium photocatalysts as sustainable alternative to precious metal-based counterparts encourages the design and efficient synthesis of distinct catalyst structures. Herein, we report our exploration of the scope of the aryne-imin

Direct synthesis of 2-substituted benzonitriles: Via alkylcyanation of arynes with N, N -disubstituted aminomalononitriles

An efficient alkylcyanation of in situ generated arynes by N,N-disubstituted aminomalononitriles is described, enabling the direct synthesis of 2-substituted benzonitriles.

A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of o-Chloro Benzoates by KCl, Arynes, CO2, and Chloroalkanes

A transition-metal-free three-phase four-component coupling reaction (3P-4CR) involving KCl, arynes, chloroalkanes and CO2 has been reported for the first time, enabling the incorporation of both chloro and CO2 into an aryne simultaneously. The reactions for the synthesis of different types of o-chloro benzoates can be selectively modulated by the chloroalkane utilized. The corresponding products can be alternatively transformed for postsynthetic functionalizations conveniently.

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

As universal heterodimer partners of many nuclear receptors, the retinoid X receptors (RXRs) constitute key transcription factors. They regulate cell proliferation, differentiation, inflammation, and metabolic homeostasis and have recently been proposed as potential drug targets for neurodegenerative and inflammatory diseases. Owing to the hydrophobic nature of RXR ligand binding sites, available synthetic RXR ligands are lipophilic, and their structural diversity is limited. Here, we disclose the computer-assisted discovery of a novel RXR agonist chemotype and its systematic optimization toward potent RXR modulators. We have developed a nanomolar RXR agonist with high selectivity among nuclear receptors and superior physicochemical properties compared to classical rexinoids that appears suitable for in vivo applications and as lead for future RXR-targeting medicinal chemistry.

Construction of Phenanthrenes and Chrysenes from β-Bromovinylarenes via Aryne Diels-Alder Reaction/Aromatization

A highly efficient transition-metal-free general method for the synthesis of polycyclic aromatic hydrocarbons like phenanthrenes and chrysenes (and tetraphene) from β-bromovinylarenes and arynes has been developed. The reactions proceed via an aryne Diels-Alder (ADA) reaction, followed by a facile aromatization. This is the first report on direct construction of chrysenes (and tetraphene) using the ADA approach. Unlike the literature method which is limited to only 9/10-substituted derivatives, this method gives access to a wide variety of functionalized phenanthrenes.

Double-ring-substituted pyrazolone azo compound, its preparation and use

The invention belongs to the fields of the pharmaceuticals and the chemical engineering, and relates to bicyclic-substituted pyrazolone azo compounds, and a preparation method and a use thereof, and concretely relates to compounds represented by formula I, or pharmaceutically acceptable salts or solvates thereof, wherein L and R1 to R6 are defined as in the specification and the claims. The invention also relates to a preparation method of the compounds of formula I, a medicinal composition of the compounds, and a medicinal use of the compounds. The compounds of formula are an effective TOP receptor stimulant, and are a good thrombocytopenia treatment drug.

Twisted baskets

A preparative procedure for obtaining a pair of twisted molecular baskets, each comprising a chiral framework with either right ((P)-1syn) or left ((M)-1syn) sense of twist and six ester groups at the rim has been developed and optim

Experimental and Theoretical Investigations of the Bromination of Phenols with β and γ Aliphatic Substituents, including Rings

Bromination reactions of substituted and ring fused phenols were studied by both experiment (t-BuNH-Br) and computation (density functional theory). The outcomes support each other, indicating a clear and predictable regioselective preference among 3,4-bis-alkylated and 3,4-ring-fused phenols.

Dihydrobiphenylenes through ruthenium-catalyzed [2+2+2] cycloadditions of ortho-alkenylarylacetylenes with alkynes

A new synthetic route to dihydrobiphenylenes has been developed. The process involves a mild RuII-catalyzed [2+2+2] dimerization of ortho-alkenylarylacetylenes or its more versatile variant, the Ru-catalyzed [2+2+2] cycloaddition of ortho-ethynylstyrenes with alkynes. Mechanistic aspects of this [2+2+2] cycloaddition are discussed. A new synthetic route to dihydrobiphenylenes involves a mild RuII-catalyzed [2+2+2] dimerization of ortho-alkenylarylacetylenes or its more versatile variant, the Ru-catalyzed [2+2+2] cycloaddition of ortho-ethynylstyrenes with alkynes. The mechanistic aspects of this [2+2+2] cycloaddition are also discussed. Copyright