3235-46-9

Usage

Uses

Used in Pharmaceutical Industry:
NSC20667 is used as an anti-cancer agent for its ability to inhibit the proliferation of cancer cells and induce cell death in various cancer types, such as breast, prostate, and leukemia. Its potential therapeutic benefits are currently being studied to fully understand its mechanisms of action.
Used in Neuroprotective Applications:
NSC20667 is used as a neuroprotective agent due to its potential to provide protection to the nervous system, which may be beneficial in the treatment of neurodegenerative diseases and conditions.
Used in Anti-inflammatory Applications:
NSC20667 is used as an anti-inflammatory agent, leveraging its ability to reduce inflammation, which could be useful in the treatment of inflammatory diseases and conditions.

InChI:InChI=1/C6H13NO2/c1-6(2,7)4-3-5(8)9/h3-4,7H2,1-2H3,(H,8,9)

Upstream product

• 5165-28-6 5,5-dimethyl-2-pyrrolidone 
• 16507-02-1 methyl 4-methyl-4-nitropentanoate 
• 5762-41-4 Benzyl-γ-nitro-γ-methylvalerat 

Relevant academic research and scientific papers

Effect of Differential Geminal Substitution of γAmino Acid Residues at the (i + 2) Position of αγTurn Segments on the Conformation of Template β-Hairpin Peptides

The effect of insertion of three geminally dimethyl substituted γamino acid residues [γ2,2 (4-amino-2,2-dimethylbutanoic acid), γ3,3 (4-amino-3,3-dimethylbutanoic acid), and γ4,4 (4-amino-4,4-dimethylbutanoic acid)] at the (i + 2) position of a two-residue αγC12 turn segment in a model octapeptide sequence Leu-Phe-Val-Aib-Xxx-Leu-Phe-Val (where Xxx = γamino acid residues) has been investigated in this study. Solution conformational studies (NMR, CD, and IR) and ab initio calculations indicated that γ3,3 and γ4,4 residues were well accommodated in the β-hairpin nucleating αγC12 turns, which gave rise to well-registered hairpins, in contrast to γ2,2, which was unable to form a tight C12 β-hairpin nucleating turn and promote a well-registered β-hairpin. Geminal disubstitution at the Cα carbon in γ2,2 led to unfavorable steric contacts, disabling its accommodation in the αγC12 hairpin nucleating turn unlike the γ3,3 and γ4,4 residues. Geminal substitutions at different carbons along the backbone constrained backbone torsion angles for the three γamino acid residues differently, generating diverse conformational preferences in them. Folded hairpins were energetically more stable (～8 to 9 kcal/mol) than the unfolded peptides. Conformational preference of the peptides was independent of the N-terminal protecting group. Such fundamental understanding will instrumentalize the future directed design of foldamers.

Bisheterocycle substituted oxa-spiro derivative, and preparation method and medical application thereof

The invention relates to a bisheterocyclic substituted oxa-spiro derivative, and a preparation method and medical application thereof. Specifically, the invention discloses compounds of formula (I) and formula (II) or pharmaceutically acceptable salts, stereoisomers or solvates thereof, and a preparation method and application thereof. Each group in the formulas is as defined in the specificationand claims in detail.

Straightforward synthesis of indolizidine alkaloid 167B

The synthetic access to indolizidines, substituted in C-5 position, was reported with good diastereoselectivity. The strategy developed was based on a key step of Michael addition associated with a Clauson-Kaas condensation.

A simple synthesis of α,β-unsaturated γ-aminobutyric acid (GABA) derivatives fron enamines

Bromination of enamines 3b-g at -78°C and subsequent treatment of the resulting iminium salts 4b-g with excess tert-butyl lithioacetate leads to tert-butyl 4-(N,N-dialkylamino)carboxylates 9b-g in good to very good yields. Ester cleavage of the dibenzylamino derivative 9d with trifluoroacetic acid yields the corresponding acid 10. Subsequent catalytic hydrogenation of 10 leads to the fully deprotected 4-amino-4-methylpentanoic acid (12) in high yield.