3235-68-5

Usage

Uses

Used in Pharmaceutical Industry:
PIPERIDIN-1-YL-ACETIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of new drug molecules. Its structural properties make it a valuable component in medicinal chemistry, contributing to the development of therapeutic agents.
Used in Organic Chemistry:
In the realm of organic chemistry, PIPERIDIN-1-YL-ACETIC ACID is utilized as a reagent and building block for a wide array of chemical reactions, enabling the formation of complex organic compounds.
Used in Agrochemical Production:
PIPERIDIN-1-YL-ACETIC ACID also serves as an intermediate in the production of agrochemicals, playing a crucial role in the synthesis of compounds used in agriculture to protect crops and enhance yields.
Used in Specialty Chemicals:
Furthermore, PIPERIDIN-1-YL-ACETIC ACID is employed in the manufacture of specialty chemicals, which are tailored for specific industries and applications, highlighting its broad utility across the chemical sector.

InChI:InChI=1/C7H13NO2.ClH/c9-7(10)6-8-4-2-1-3-5-8;/h1-6H2,(H,9,10);1H

Upstream product

• 23853-10-3 piperidin-1-yl-acetic acid ethyl ester 
• 110-89-4 piperidine 
• 5292-43-3 bromoacetic acid tert-butyl ester 

Downstream Products

• 1314962-40-7 4-acetamidophenyl 2-(piperidin-1-yl)acetate hydrochloride 
• 1314962-48-5 4-acetamidophenyl 2-(piperidin-1-yl)acetate 

Relevant academic research and scientific papers

Selective 1,2-Aryl-Aminoalkylation of Alkenes Enabled by Metallaphotoredox Catalysis

A highly chemo- and regioselective intermolecular 1,2-aryl-aminoalkylation of alkenes by photoredox/nickel dual catalysis is described here. This three-component conjunctive cross-coupling is highlighted by its first application of primary alkyl radicals, which were not compatible in previous reports. The readily prepared α-silyl amines could be transferred to α-amino radicals by photo-induced single electron transfer step. The radical addition/cross-coupling cascade reaction proceeds under mild, base-free and redox-neutral conditions with good functional group tolerance, and importantly, provides an efficient and concise method for the synthesis of structurally valuable α-aryl substituted γ-amino acid derivatives motifs.

Tandem Palladium and Isothiourea Relay Catalysis: Enantioselective Synthesis of α-Amino Acid Derivatives via Allylic Amination and [2,3]-Sigmatropic Rearrangement

A tandem relay catalytic protocol using both Pd and isothiourea catalysis has been developed for the enantioselective synthesis of α-amino acid derivatives containing two stereogenic centers from readily accessible N,N-disubstituted glycine aryl esters and allylic phosphates. The optimized process uses a bench-stable succinimide-based Pd precatalyst (FurCat) to promote Pd-catalyzed allylic ammonium salt generation from the allylic phosphate and the glycine aryl ester. Subsequent in situ enantioselective [2,3]-sigmatropic rearrangement catalyzed by the isothiourea benzotetramisole forms syn-α-amino acid derivatives with high diastereo- and enantioselectivity. This methodology is most effective using 4-nitrophenylglycine esters and tolerates a variety of substituted cinnamic and styrenyl allylic ethyl phosphates. The use of challenging unsymmetrical N-allyl-N-methylglycine esters is also tolerated under the catalytic relay conditions without compromising stereoselectivity.

NOVEL TECHNETIUM AND RHENIUM COMPLEXES

Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhen

Pyrimidine derivatives and processes for the preparation thereof

The present invention relates to novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof which possess an excellent anti-secretory activity, pharmaceutical compositions containing the same as an active ingredient, their novel intermediates, and processes for the preparation thereof wherein: when A is piperidin-1-yl or —NH—B, wherein B is C3-C4alkyl, C3-C4alkenyl, C3-C7cycloalkyl, C1-C3alkoxyethyl, phenylethl which may be substituted or unsubstituted, 3-trifluoromethylphenylmethyl, 1-naphthylmethyl, 4-methylthiazol-2-yl or 4-phenylthiazol-2-yl, R1is hydrogen or methyl; and R2, R3, R4and R5are hydrogen; or when A is a group of formula (II); when R1is hydroxymethyl or C1-C3alkoxymethyl, R2, R3, R4, R5and R6are hydrogen; and R7is hydrogen or halogen; or when R1is hydrogen or methyl, R7is hydrogen or halogen; and one or two of R2, R3, R4, R5and R6is hydroxy, methoxy, or a group of formula (III) wherein Z is C1-C4alkyl, substituted or unsubstituted C1-C4alkenyl, cyloalkyl, benzyloxyalkyl, alkoxycarbonylalkyl, morpholinomethyl, piperidinomethyl, 4-substituted-piperazinomethyl, substituted or unsubstituted phenyl, naphthyl, substituted or unsubstituted benzyl, thiophen-2-yl-methyl, 1-substituted-pyrrolidin-2-yl or —CHR8NHR9, wherein R8is hydrogen, methyl, isopropyl, benzyl, benzyloxymethyl, methylthioethyl, benzyloxycarbonylmethyl, carbamolymethyl, carbamoylethyl, or 1-benzylimidazol-4-ylmethyl and R9is hydrogen or t-butoxycarbonyl; and the others are hydrogen or methyl.

Aqueous basicity and proton affinity of zwitterionic ω-(N-methylpiperidine)-alkanocarboxylates and ω-(N-piperidine)-alkanocarboxylic acids

The pK a values of 5 ω-(N-methylpiperidine)-alkanocarboxylates (N-methylpiperidine betaines) and 5 ω-(N-piperidine)-alkanocarboxylic acid were determined by potentiometric titration of their hydrohalides with KOH. Semiempirical geometry optimizations were performed for gaseous betaines. Four conformers were characterized and their PA values estimated. The PA values fulfilled the linear correlation with the aqueous pKa values estimated in ref. 1. A linear correlation between the calculated heat of formation (ΔHt) and the sum of the N...O1 and N...O2 distances, for the conformers containing the same number of CH2 groups, indicates that they are stabilized by the intramolecular electrostatic interactions between the positively charged nitrogen atom and oxygen atoms of the carboxylate group.

Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylmercapto derivatives

The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia.

AMINOACETYLMERCAPTO DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

The present invention relates to novel aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ACE.