323579-75-5

Upstream product

• 104637-89-0 (E)-enol lactone of β-(p-chlorobenzoyl)-α-(2-furfurylidene)propionic acid 

Downstream Products

• 432542-74-0 N-(N'-{2-[2-(4-chloro-phenyl)-2-oxo-ethyl]-3-furan-2-yl-acryloyl}-hydrazinocarbonyl)-4-methyl-benzenesulfonamide 
• 654075-49-7 Benzoic acid N'-{4-(4-chloro-phenyl)-2-[1-furan-2-yl-meth-(E)-ylidene]-4-oxo-butyryl}-hydrazide 

Relevant academic research and scientific papers

Conversion of 2(3H)-furanones into 1,3,4-oxadiazoles

A series of 2-phenyl-5-alkenyl-1,3,4-oxadiazoles were synthesized in high yields from the corresponding dicarbonylhydrazides through cyclodehydration.

A facile method for the synthesis of 6-aryl-1-(3-chloropropanoyl)-4-[(E)-1- (2-furyl)methylidene)]-1,2,3,4-tetrahydr o-3-pyridazinones and 2-(2-chloroethyl)-5-[α-aracyl-β-(2-furyl)]-(E )-vinyl-1,3, 4-oxadiazoles

The 6-aryl-1-(3-chloropropanoyl)-4-[(E)-1-(2-furyl)methylidene)]-1,2,3,4- tetra-hydro-3-pyridazinones (6a-d) were synthesized by the reaction of acid chloride 3 with α-aracyl(β-2-furyl)acrylic acid hydrazides (2a-d) in a high yield, one pot reaction. On the other hand, 2-(2-chloroethyl)-5-[α- aracyl-β-(2-furyl)]-(E)-vinyl-1,3,4-oxadiazoles (7a-d) were also prepared by cyclodehydration of N1[α-aracyl-β-(2-furyl)acroyl- N2[3-chloro-propanoyl] hydrazine derivatives (4a-d). The proposed structures of the products were confirmed by elemental analysis, spectral data and chemical evidence.