323579-86-8

Upstream product

• 124605-42-1 methyl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropionate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 195624-97-6 (2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester 
• 157240-36-3 (2R,3S)-3-phenylisoserine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 60512-85-8 (E)-isopropyl cinnamate 
• 140-10-3 (E)-3-phenylacrylic acid 

Downstream Products

• 873914-61-5 (2R,3S)-2-[(tert-butyldimethyl-silanyloxy)-3-hydroxy-1-phenylpropyl]-carbamic acid tert-butyl ester 
• 873914-63-7 (4S,5S)-5-(tert-butoxycarbonylamino)-4-hydroxy-5-phenylpentanoic acid ethyl ester 
• 873914-62-6 (4S,5S)-5-tert-butoxycarbonylamino-4-(tert-butyldimethylsilanyloxy)-5-phenylpent-2-enoic acid ethyl ester 
• 148700-85-0 L 733060 
• 159249-47-5 tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate 
• 562817-60-1 (2S,3S)-1-(tert-butyloxycarbonyl)-2-phenyl-3-[(3,5)-bis(trifluoromethyl)benzyloxy]piperidine 
• 691871-80-4 (4S,5S)-(2,5-dihydroxy-1-phenylpentyl)-carbamic acid tert-butyl ester 
• 323580-16-1 C₆₆H₁₀₄N₄O₁₁Si₄ 
• 323580-07-0 3-[3-[3-tert-butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid methyl ester 
• 323579-99-3 3-[3-tert-butoxycarbonylamino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionic acid methyl ester 

Relevant academic research and scientific papers

An asymmetric aminohydroxylation route to (+)-L-733,060

An enantioselective synthesis of (+)-L-733,060 starting from cinnamic acid using Sharpless asymmetric aminohydroxylation and Wittig reactions as the key steps is described.

Phenylisoserine: A versatile amino acid for the construction of novel β-peptide structures

The N-Boc O-tert-butyldimethysilyl-substituted hexa-β-peptide methyl ester 18 was constructed from the O-TBS ether of (-)-(2R, 3S)-phenylisoserine. By NMR, it was determined that this homo β-peptide adopts a highly stable β-strand-type secondary structure