32363-18-1

Basic information

• Product Name: N-(4-methoxyphenyl)-N-methyltrifluoroacetamide
• Synonyms: N-(4-methoxyphenyl)-N-methyltrifluoroacetamide
• CAS NO: 32363-18-1
• Molecular Weight: 233.19
• Mol File: 32363-18-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-N-methyltrifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-N-methyltrifluoroacetamide(32363-18-1)
• EPA Substance Registry System: N-(4-methoxyphenyl)-N-methyltrifluoroacetamide(32363-18-1)

Safety Data

• Hazardous Substances Data: 32363-18-1(Hazardous Substances Data)

Upstream product

• 431-47-0 trifluoroacetic acid-methyl ester 
• 332-34-3 2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetamide 
• 407-25-0 trifluoroacetic anhydride 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 

Downstream Products

• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 

Relevant articles and documents

Method for selective N-methylation of secondary amide

The invention relates to a method for selective N-methylation of secondary amide. The method is characterized in that the secondary amide is in an organic solvent N, N-dimethyl formamide or dimethyl sulfoxide, trifluoroacetic acid methyl ester serves as a methylation reagent, and reaction is performed in the presence of sodium hydride, potassium tert-butoxide or sodium methylate, so as to obtain aselective N-methylated product. The method has the characteristics that generally a trifluoroacetylation product is produced when the trifluoroacetic acid methyl ester is reacted with amine compounds, however a N-methylated product can be selectively obtained when the trifluoroacetic acid methyl ester is reacted with secondary amide; the method is simple to operate, low in cost, mild in reactionconditions and high in selectivity, and avoids the use of hypertoxic methylation reagents, such as dimethyl sulfate and methyl iodide.