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Usage

Uses

Used in Pharmaceutical Industry:
IMETIT DIHYDROBROMIDE is used as a research compound for studying the histamine H3 and H4 receptors, which play a crucial role in various physiological processes and are potential targets for the development of new therapeutic agents. Its agonistic activity at these receptors makes it a valuable tool in understanding the mechanisms of histamine signaling and its potential applications in treating various conditions.
Used in Neurological Research:
IMETIT DIHYDROBROMIDE is used as a central nervous system agent due to its ability to modulate histamine levels in the brain. This property makes it a potential candidate for the development of drugs targeting neurological disorders and conditions related to histamine dysregulation.
Used in Allergy and Immunology Research:
IMETIT DIHYDROBROMIDE is used as an immunomodulatory agent due to its ability to induce shape change in eosinophils, which are involved in allergic reactions and immune responses. This characteristic makes it a potential tool for studying the role of histamine in allergic diseases and developing new treatments for these conditions.
Used in Drug Development:
IMETIT DIHYDROBROMIDE is used as a lead compound in the development of new drugs targeting histamine H3 and H4 receptors. Its high affinity and selectivity for these receptors make it a promising starting point for designing more potent and selective therapeutic agents for various diseases and conditions.

Biological Activity

An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset? .

Biochem/physiol Actions

Potent and selective H3 histamine receptor agonist.

InChI:InChI=1/C6H10N4S.2BrH/c7-6(8)11-2-1-5-3-9-4-10-5;;/h3-4H,1-2H2,(H3,7,8)(H,9,10);2*1H