32386-87-1

Usage

Chemical class

Isoquinolines

Structure

Bicyclic, heterocyclic compound

Form

Hydrochloride salt form of 2,3-dihydro-1H-isoquinoline

Research and pharmaceutical applications

Potential antipsychotic and anticonvulsant agent

Neurotransmitter systems affected

Serotonin, dopamine, and glutamate

Potential treatment uses

Psychiatric and neurological disorders, drug addiction, and withdrawal symptoms

InChI:InChI=1/C12H11N.ClH/c1-3-9-4-2-6-11-8-13-7-10(5-1)12(9)11;/h1-6,13H,7-8H2;1H

Upstream product

• 22817-39-6 2-benzyl-2,3-dihydro-1H-benz[de]isoquinoline; hydrochloride 

Downstream Products

• 81585-13-9 N-(4-Nitro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine 
• 81585-09-3 N-(4-Methoxy-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine 
• 81585-07-1 N-(4-Chloro-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine 
• 81585-15-1 N-(4-Amino-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine 
• 81580-75-8 N-Phenyl-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine 
• 81585-20-8 N-(4-Sulfamoyl-phenyl)-3a,4,5,6-tetrahydro-1H,3H-benzo[de]isoquinoline-2-carboxamidine 

Relevant academic research and scientific papers

Inhibitors of Bllod Platelet Aggregation. Activity of Some 1H-Benzisoquinolinecarboximidamides on the in Vivo Blood Platelet Aggregation Induced by Collagen

A series of 33-1H-benzisoquinolinecarboximidamides has been prepared and tested in the rat after intraperitoneal (ip) and/or oral (po) administration for their ability to inhibit the in vivo blood platelet aggregation induced by colagen.In this aggregation test, a considerable number of active compounds were found.Fourteen compounds were active when administred ip , five of which also exhibited significant po activity.One compound was toxic after ip administration but was found to be active after po administration without apparent toxicity.Itis thought that the solubility of the drug in water is an important factor for the resorption after oral administration and, hence, for its oral activity.