324-61-8Relevant academic research and scientific papers
Switchable Cobalt-Catalyzed α-Olefination and α-Alkylation of Nitriles with Primary Alcohols
Paudel, Keshav,Xu, Shi,Ding, Keying
, p. 5028 - 5032 (2021)
The first switchable α-olefination and α-alkylation of nitriles with primary alcohols catalyzed by a well-defined base transition-metal Co complex was presented. A broad variety of nitriles and primary alcohols are selectively and efficiently converted to the corresponding products by this method. It is noteworthy that the transformation is environmentally benign and atom efficient with H2and H2O being the sole byproducts.
Dialkylamino cyclopentadienyl ruthenium(II) complex-catalyzed α-alkylation of arylacetonitriles with primary alcohols
Cheung, Hung Wai,Li, Juan,Zheng, Wenxu,Zhou, Zhongyuan,Chiu, Yu Hin,Lin, Zhenyang,Lau, Chak Po
experimental part, p. 265 - 274 (2010/03/04)
Aminocyclopentadienyl ruthenium complexes, [(η5-C 5H4NMe2)Ru(PPh3)2(CH 3CN)]+BF4- and [(η5- C5H4NEt2)Ru(PPh3) 2(CH3CN)]+BF4-, are moderately active catalysts for α-alkylation of arylacetonitriles with primary alcohols; on the other hand, the analogous unsubstituted cyclopentadienyl ruthenium complex [(η5-C5H 5)Ru(PPh3)2(CH3CN)] +BF4- shows very low catalytic activity. On the basis of experimental results and theoretical calculations, rationalization for the much higher catalytic activity of the aminocyclopentadienyl complexes over that of the unsubstituted Cp complex is provided. In the catalytic systems with the former, it is possible to regenerate the active solvento complexes via protonation of the metal hydride intermediates and subsequent ligand substitution; this process is, however, very nonfacile in the catalytic system with the latter. The Royal Society of Chemistry 2010.
