3240-24-2

Usage

Uses

Used in Pharmaceutical Applications:
1-(1-methylpyridin-4(1H)-ylidene)-N-oxoethanaminium is used as a potential pharmaceutical compound for [application reason]. Its specific application reason should be determined based on further research and testing, as the provided materials do not specify a particular use in this industry.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(1-methylpyridin-4(1H)-ylidene)-N-oxoethanaminium is used as a chemical intermediate for [application reason]. The exact role it plays in organic synthesis would depend on the specific reactions and goals of the synthesis process, which are not detailed in the provided materials.
Used in Chemical Reactions:
As an intermediate in chemical reactions, 1-(1-methylpyridin-4(1H)-ylidene)-N-oxoethanaminium is used for [application reason]. The exact application reason would be based on the particular reactions in which 1-(1-methylpyridin-4(1H)-ylidene)-N-oxoethanaminium is utilized, which are not specified in the provided materials.

Upstream product

• 1194-99-6 4-acetylpyridine oxime 
• 74-88-4 methyl iodide 
• 76241-84-4 4-(1-Hydroxy-1-hydroxyamino-ethyl)-1-methyl-pyridinium; iodide 

Relevant academic research and scientific papers

Nucleophilic addition to 4-acetyl-1-methylpyridinium iodide studied by 1H nmr

The 1H nuclear magnetic resonance spectra obtained during the addition of amines to 4-acetyl-1-methylpyridinium iodide in aqueous solution provide data for the kinetic parameters associated with:(1) the rapid equilibrium of the addition step to form the carbinolamine intermediate; (2) the rate determining dehydration step to form the syn and anti imines; and (3) the anti to syn isomerization.Depending on the amine used, (1) can result in methyl proton exchange that is either fast or slow relative to the chemical shift between the acetyl-CH3 resonance of 4-acetyl-1-methylpyridinium iodide and the corresponding one due to carbinolamine.The line width data and the equilibrium constant Kn, which is determined by flow uv, provide values for the rate constants (kn and k-n) of the forward and reverse steps of the equilibrium.The logarithm of kn does not correlate with log Kn or pKa of the amines.In addition, the enthalpy change ΔH for the equilibrium step is found not to depend significantly on the nature of the amine.It remains relatively constant at about -11 kcal M-1.The dehydration step is subject to general acid and base catalysis with the effect decreasing in the order hydrazine, hydroxylamine, semicarbazide, and methoxyamine.For hydrazine and hydroxylamine, the syn/anti ratios are pH dependent.For hydrazine and semicarbazide the anti to syn imine conversion depends on pH.The occurence of anti to syn isomerism indicates that the dehydration of carbinolamine gives the anti imine as the product of kinetic control.