324024-00-2Relevant academic research and scientific papers
Palladium catalyzed hydrodefluorination of fluoro-(hetero)arenes
Gair, Joseph J.,Grey, Ronald L.,Giroux, Simon,Brodney, Michael A.
supporting information, p. 2482 - 2487 (2019/04/10)
Palladium catalyzed hydrodefluorination was developed for fine-tuning the properties of fluoro-(hetero)aromatic compounds. The robust reaction can be set up in air, requires only commercially available components, and tolerates a variety of heterocycles and functionalities relevant to drug discovery. Given the prevalence of fluorine incorporation around metabolic hotspots, the corresponding deuterodefluorination reaction may prove useful for converting fluorinated libraries to deuterated analogues to suppress the oxidative metabolism by kinetic isotope effects.
Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps
Wei, Peng,Kaatz, Glenn W.,Kerns, Robert J.
, p. 3093 - 3097 (2007/10/03)
In this study the chemical modification of paroxetine was employed to determine which structural differences between the paroxetine-like and femoxetine-like selective serotonin reuptake inhibitors is responsible for the differential potency of these agent
Etherification and dealkylation of piperidine derivatives and intermediates
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, (2008/06/13)
The invention relates to a novel chemical process for pre-paring 4-phenylpiperidines having calcium overload blocking activity and antidepressant activity, and to novel interme-diates used in that process.
