324026-57-5Relevant academic research and scientific papers
Silver-catalyzed chemoselective annulation of propargyl amines with alkynes for access to pyridines and pyrroles
Nizami, Tauqir A.,Hua, Ruimao
, p. 6080 - 6084 (2017/09/23)
The annulation of propargyl amines with electron-deficient alkynes in the presence of silver salts affording pyridines and pyrroles has been developed. The chemoselective [4+2] or [3+2] annulation approach to pyridines or pyrroles depends on the structure
Synthesis of polysubstituted pyrroles from activated alkynes and n-propargylamines through base-catalyzed cascade reaction
Weng, Jianquan,Chen, Yong,Yue, Binjie,Xu, Meng,Jin, Hongwei
, p. 3164 - 3170 (2015/05/13)
A novel K3PO4-catalyzed synthesis of polysubstituted pyrroles by a Michael addition/alkyne carbocyclization of activated alkynes and N-propargylamines has been developed. This transition-metal-free cascade process represents an environmental friendly and efficient way to construct polysubstituted pyrroles in good yields. Catalyzed by CsF, a Michael addition/aza-Claisen rearrangement/cyclization sequential process has been achieved to selectively synthesize pyrroles in moderate yields. An efficient method for the synthesis of polysubstituted pyrroles from activated alkynes and N-propargylamines has been developed. This cascade process represents an atom- and step-economical way to construct a range of polysubstituted pyrroles and involves base-catalyzed Michael addition/alkyne carbocyclization or Michael addition/aza-Claisen rearrangement/cyclization.
Syntheses of new 5,6,7,8-tetrahydropyrrolo [2,3-d]azepine ring system
Waly
, p. 217 - 221 (2007/10/03)
A first synthesis of pyrrolo[2,3-d]azepine ring system starting from pyrrole and perhydroazepine derivatives was reported. In addition, Lansbury's reaction is developed through the use of para-toluene sulphonic acid (p-TsOH) as a new catalyst for this reaction.
