324043-56-3

Upstream product

• 37441-50-2 1,4-butanesultam 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 324043-54-1 4-benzoyl-4-chlorobutanesulfonanilide 

Downstream Products

• 324043-58-5 4-(tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl)benzophenonecyanoacetohydrazone 
• 324043-66-5 (E)-3-ethoxycarbonyl-4-phenyl-4-(4'-tetrahydro-1,2-thiazine-1,1-dioxide-2-yl)phenyl-3-butenoic acid 
• 324043-70-1 4-acetoxy-2-ethoxycarbonyl-1-phenyl-6-(tetrahydro-1,2-thiazin-1,1-dioxide-2-yl)-naphthalene 
• 324043-72-3 6-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-4-hydroxy-1-phenyl-naphthalene-2-carboxylic acid 
• 324043-74-5 6-(1,1-dioxo-1λ⁶-[1,2]thiazinan-2-yl)-4-methoxy-1-phenyl-naphthalene-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of N-arylated sultams: Palladium- and copper-catalyzed cross coupling of aryl halides with 1,4-butane and 1,3-propanesultams

Palladium-catalyzed cross coupling of 1,4-butanesultam and 1,3-propanesultam with a variety of aryl halides was found to provide the desired products in 62-93% isolated yield using Xantphos as ligand. The Pd-catalyzed reaction was found to be superior to the analogous Cu-catalyzed reaction based on product yields, reaction rates, and substrate scope.

Synthesis of sultam derivatives with expected biological activity. 15

4-(Trihydro-2H-1,2-thiazole-1,1-dioxide-2-yl)benzophenone (1), 4-(3,5-dimethyl-1′,2′-thiazine-1′,1′-dioxide-2-yl) benzophenone (2), and 4-(tetrahydro-2H-1,2-thiazine-1,1-dioxide-2-yl) benzophenone (6) were obtained from 4-aminobenzophenone and the appropriate reagents. Isomeric (E-) and (Z-) 2-Ethoxycarbonyl-4-phenyl-4-(4-tetrahydro-1,2- thiazine-1,1-dioxide-2-yl)phenyl-3-butenoic acids (11 and 12) and 2-carboxy-4(N-phenyl-thiocarbamoyl)-1-phenyl-6-(tetrahydro-2H-1,2-thiazine-1, 1-dioxide-2-yl)naphthalene (16) were also synthesized.