324075-76-5

Basic information

• Product Name: 1,3-Dioxolo[4,5-g]isoquinoline, 8-(trifluoromethyl)-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-
• CAS NO: 324075-76-5
• Molecular Formula: C20H11F6NO2
• Molecular Weight: 411.303
• Mol File: 324075-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolo[4,5-g]isoquinoline, 8-(trifluoromethyl)-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolo[4,5-g]isoquinoline, 8-(trifluoromethyl)-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-(324075-76-5)
• EPA Substance Registry System: 1,3-Dioxolo[4,5-g]isoquinoline, 8-(trifluoromethyl)-5-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-(324075-76-5)

Safety Data

• Hazardous Substances Data: 324075-76-5(Hazardous Substances Data)

Upstream product

• 102124-73-2 α,α,α-trifluoro-3,4-methylenedioxyacetophenone 
• 324076-80-4 4-methoxy-6,7-methylenedioxy-4-trifluoromethyl-1-[4-(trifluoromethyl)styryl]-3,4-dihydroisoquinoline 
• 324076-79-1 N-[2-methoxy-2-(3,4-methylenedioxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 324075-40-3 4-methoxy-1-methyl-6,7-methylenedioxy-4-trifluoromethyl-3,4-dihydroisoquinoline 
• 324075-42-5 1-methyl-6,7-methylenedioxy-4-(trifluoromethyl)isoquinoline 
• 105919-36-6 trans-4-(trifluoromethyl)cinnamoyl chloride 
• 324075-38-9 N-[2-methoxy-2-(3,4-methylenedioxyphenyl)-2-(trifluoromethyl)ethyl]acetamide 
• 324075-64-1 3,3,3-trifluoro-2-methoxy-2-(3,4-methylenedioxyphenyl)propylamine 
• 324075-63-0 3,3,3-trifluoro-2-methoxy-2-(3,4-methylenedioxyphenyl)propionitrile 

Relevant articles and documents

Synthesis of 4-(trifluoromethyl)isoquinolines. Influence of trifluoromethyl group on the Pictet-Gams ring closure reaction

Treatment of N-acyl-2-methoxy-2-(trifluoromethyl)arylethylamines under Pictet-Gams conditions afforded 4-methoxy-4-trifluoromethyl-3,4-dihydroisoquinolines which were aromatised by base catalysed methanol elimination. Earlier we described the synthesis of 2-oxazolines by conducting the Pictet-Gams sequence with N-acyl-2-hydroxy-2-(trifluoromethyl)arylethylamines. The operation of these two pathways is explained by the influence of the trifluoromethyl group.