3241-76-7

Usage

Uses

Used in Pharmaceutical Industry:
N-(3,4-dimethoxybenzyl)-2-phenylethanamine is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential to contribute to the development of new medications.
Used in Medicinal Chemistry:
It serves as a structural component in drug discovery, potentially enhancing the properties of new chemical entities due to its unique arrangement of functional groups.
Used in Chemical Synthesis:
N-(3,4-dimethoxybenzyl)-2-phenylethanamine is used as a precursor in the synthesis of other chemicals, leveraging its reactivity and structural attributes to produce a range of compounds for various applications.
Further research and experimentation are necessary to fully explore and exploit the chemical characteristics and potential uses of N-(3,4-dimethoxybenzyl)-2-phenylethanamine, particularly in the context of its applications in medicinal chemistry and drug discovery.

Upstream product

• 3241-17-6 N-(3,4-dimethoxybenzylidene)-2-phenylethanamine 
• 64-04-0 phenethylamine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 116760-21-5 methyl-phenethyl-veratryl-amine 

Relevant academic research and scientific papers

Synthesis, structure-activity relationship and in vitro biological evaluation of N-arylethyl isoquinoline derivatives as Coxsackievirus B3 inhibitors

Currently, there is no approved antiviral drug for the infection caused by enteroviruses. A series of novel N-arylethyl isoquinoline derivatives defined with substituents on the ring A and C were designed, synthesized and evaluated in vitro for their activities against Coxsackievirus B3 (CVB3). The primary structure-activity relationship revealed that substituents on the ring A were not beneficial for the activity. Among these analogs synthesized, compound 7f bearing a methylenedioxy at the R4 and R5 positions afforded an anti-CVB3 activity and a reasonable selectivity index (SI = 26.8); furthermore, 7f exhibited a moderate activity against enterovirus 71 (EV71) with SI value of 9.0. Thus it has been selected as an anti-enteroviral lead compound for further investigation.

A Convenient Synthesis of Apogalanthamine Analogues as α-Adrenergic Blocking Agents using Zerovalent Nickel

The apogalanthamine analogues, 5,6,7,8-tetrahydrodibenzazocine (2) and its N-methyl and N-acetyl derivatives (1 and 3), and the methoxy derivatives (4, 5 and 9) of (1) were obtained in good yields by cyclization of the corresponding halogeno-N-benzyl-β-phenethylamines (10a, 11a-d, 12a,b and 13a-c) using stoichiometric amounts of zerovalent nickel generated in situ and potassium iodide.