32418-96-5Relevant academic research and scientific papers
4-Amino-1,2-dithiolane-4-carboxylic acid (Adt) as cysteine conformationally restricted analogue. Synthetic protocol for Adt containing peptides
Morera, Enrico,Nalli, Marianna,Pinnen, Francesco,Rossi, Domenico,Lucente, Gino
, p. 1585 - 1588 (2007/10/03)
An efficient and versatile protocol to incorporate the achiral and C(α,α)-tetrasubstituted 4-amino-1,2-dithiolane-4-carboxylic acid Adt (1) residue into peptides is described. The 2,2-bis[(benzylthio)methyl]glycine N-carboxy anhydride (5) was found to be the key reactive intermediate from which both Boc-Adt-OMe (8) and the glutathione analogue H-Glu(-Adt-Gly-OH)-OH (12) can be obtained. (C) 2000 Elsevier Science Ltd. All rights reserved.
5,5-Disubstituted Hydantoins: Syntheses and Anti-HIV Activity
Comber, Robert N.,Reynolds, Robert C.,Friedrich, Joyce D.,Manguikian, Roupen A.,Buckheit, Robert W.,et al.
, p. 3567 - 3572 (2007/10/02)
A series of 5,5-disubstituted hydantoin derivatives was synthesized by alkylating 5,5-bis(mercaptomethyl)-2,4-imidazolidinedione (3) with various halomethylaromatic or halomethylheteroaromatic precursors, or by using the Buchener-Berg procedure on the required ketone.When evaluated for their ability to inhibit HIV-induced cell killing and virus production in CEM or MT-2 cells only compounds 2, 4n, 4o, and 4i demonstrated modest activity, the latter with an IC50 = 53 μM
