3242-53-3

Upstream product

• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 7425-53-8 ethyl 4-iodobutyrate 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 1459-32-1 C₁₂H₁₂O₄ 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 35444-44-1 methyl adipoyl chloride 
• 92848-16-3 4-(4-hydroxy-2-oxo-2,5,6,7-tetrahydro-cyclopenta[b]pyran-3-yl)-butyric acid 
• 94259-91-3 2-(5-Aethoxycarbonyl-valeryl)-adipinsaeure-diaethylester 

Downstream Products

• 105089-92-7 α-5,15-<2,2'-(6-oxoundecamethylenedicarbonylamino)diphenyl>:β,β-10,20-bis(o-aminophenyl)porphyrin 
• 116306-70-8 C₅₅H₄₈N₄O₅ 
• 116288-31-4 C₅₅H₄₈N₄O₅ 

Relevant academic research and scientific papers

Synthesis and glutathione S-transferase structure-affinity relationships of nonpeptide and peptidase-stable glutathione analogues

A series of nonpeptidic glutathione analogues where the peptide bonds were replaced by simple carbon-carbon bonds or isosteric E double bonds were prepared. The optimal length for the two alkyl chains on either side of the mercaptomethyl group was evaluated using structure-affinity relationships. Affinities of the analogues 14a-f, 23, and 25 were evaluated for a recombinant GST enzyme using a new affinity chromatography method previously developed in our laboratory. Analysis of these analogues gives an additional understanding for GST affinity requirements: (a) the carbon skeleton must conserve that of glutathione since analogue 14a showed the best affinity (IC50 = 5.2 μM); (b) the GST G site is not able to accommodate a chain length elongation of one methylene group (no affinity for analogues 14c,f); (c) a one-methylene group chain length reduction is tolerated, much more for the 'Glu side' (14d, IC50 = 10.1 μM) than for the 'Gly side' (14b, IC50 = 1800 μM); (d) the mercaptomethyl group must remain at position 5 as shown from the null affinity of the 6-mercaptomethyl analogue 14e; (e) the additional peptide isosteric E double bond (25) or hydroxyl derivative (23) in 14e did not help to retrieve affinity. This work reveals useful information for the design of new selective nonpeptidic and peptidase-stable glutathione analogues.

α-Cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents

A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3-1.0 μM range