32434-42-7 Usage
Chemical Properties
White Solid
Uses
rac-Febrifugine dihydrochloride is the salt of Febrifugine, a bioactive constituent of a Chinese medicinal herb that is characterized by its therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases.
Biochem/physiol Actions
Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 32434-42-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,3 and 4 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 32434-42:
(7*3)+(6*2)+(5*4)+(4*3)+(3*4)+(2*4)+(1*2)=87
87 % 10 = 7
So 32434-42-7 is a valid CAS Registry Number.
32434-42-7Relevant articles and documents
Stereoselective total synthesis of all the stereoisomers of (+)- and (?)-febrifugine and halofuginone
Perali, Ramu Sridhar,Bandi, Anjaneyulu
, (2020/07/04)
A convenient method for the total synthesis of all the stereoisomers of febrifugine and halofuginone using D-arabinose and L-arabinose as the key starting materials is reported. Apart from the inherent stereocenters in these pentose sugars, the method utilizes the selective hydrogenolysis of the anomeric O-benzyl group, stereoselective Grignard reaction and Wacker oxidation as the key steps to obtain the important precursors for the total synthesis.
