32435-60-2 Usage
Uses
Used in Pharmaceutical Industry:
4-Chloro-3-hydroxyquinoline is used as an antimalarial agent for its potential to combat malaria-causing parasites.
4-Chloro-3-hydroxyquinoline is used as an antibacterial agent for its capacity to inhibit bacterial growth, offering a potential solution for treating bacterial infections.
4-Chloro-3-hydroxyquinoline is used as an anticancer agent for its potential to inhibit the growth of cancer cells, making it a candidate for cancer treatment research.
Used in Agrochemical Industry:
4-Chloro-3-hydroxyquinoline is used as a building block in the synthesis of various agrochemicals, contributing to the development of pesticides and other agricultural chemicals.
Used in Organic Chemistry:
4-Chloro-3-hydroxyquinoline is used as a precursor in the synthesis of biologically active molecules, playing a crucial role in creating new compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 32435-60-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,3 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 32435-60:
(7*3)+(6*2)+(5*4)+(4*3)+(3*5)+(2*6)+(1*0)=92
92 % 10 = 2
So 32435-60-2 is a valid CAS Registry Number.
32435-60-2Relevant academic research and scientific papers
Xu, Fuchao,Merkley, Amanda,Yu, Dayu,Zhan, Jixun
, p. 5262 - 5265 (2016)
Rdc2 is a flavin-dependent halogenase from Pochonia chlamydosporia. Through the introduction of a His6-tag to both the N- and C-termini, the isolation yield of Rdc2 from Escherichia coli using Ni-NTA affinity chromatography was increased by three-fold. In vitro reaction of Rdc2 and a flavin reductase (Fre) with seven different hydroxyquinolines revealed that 3-hydroxyquinoline (3), 5-hydroxyquinoline (5), 6-hydroxyquinoline (6), and 7-hydroxyquinoline (7) can be specifically halogenated. These products were prepared by incubating the corresponding substrates with IPTG-induced E. coli BL21(DE3)/Rdc2. They were respectively characterized as 3-hydroxy-4-chloroquinoline (3a), 5-hydroxy-6-chloroquinoline (5a), 5-chloro-6-hydroxyquinoline (6a), and 7-hydroxy-8-chloroquinoline (7a) by NMR and MS analyses. This work represents the first enzymatic preparation of chlorohydroxyquinolines and provides a ‘green’ method to synthesize this group of medicinally important compounds.
