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Cochlioquinone B, a minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH-ubiquinone reductase inhibitor and a phytotoxic agent that inhibits root growth. It is closely related to Cochlioquinone A, which inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have also been shown to be antagonists of the human chemokine receptor, CCR5, in HIV-1.

32450-26-3

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32450-26-3 Usage

Uses

Used in Pharmaceutical Industry:
Cochlioquinone B is used as an NADH ubiquinone reductase inhibitor for its potential role in the development of novel therapeutic agents targeting various diseases. Its ability to inhibit this enzyme may provide insights into the treatment of conditions related to cellular energy metabolism.
Used in Agriculture:
As a phytotoxic agent, Cochlioquinone B is used to inhibit root growth in plants, which can be beneficial in controlling the growth of unwanted vegetation or in studying the effects of various compounds on plant development.
Used in HIV-1 Treatment:
Cochlioquinone B is used as an antagonist of the human chemokine receptor, CCR5, for its potential application in the treatment of HIV-1. By blocking this receptor, Cochlioquinone B may help prevent the virus from entering host cells, thus limiting the progression of the disease.
Used in Nematocidal Applications:
Cochlioquinone B is used as a nematocide due to its close relation to Cochlioquinone A, which exhibits nematocidal activity. This property may be useful in the development of compounds to control and eliminate harmful nematodes in various settings, such as agriculture and environmental management.

Check Digit Verification of cas no

The CAS Registry Mumber 32450-26-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,4,5 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 32450-26:
(7*3)+(6*2)+(5*4)+(4*5)+(3*0)+(2*2)+(1*6)=83
83 % 10 = 3
So 32450-26-3 is a valid CAS Registry Number.
InChI:InChI=1/C28H40O6/c1-8-15(2)23(30)16(3)17-13-19(29)18-14-20-27(6)11-9-21(26(4,5)32)33-22(27)10-12-28(20,7)34-25(18)24(17)31/h13,15-16,20-22,32H,8-12,14H2,1-7H3/t15-,16-,20+,21+,22+,27+,28+/m0/s1

32450-26-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,4aR,6aR,12aR,12bR)-3-(2-hydroxypropan-2-yl)-6a,12b-dimethyl-9-[(2S,4S)-4-methyl-3-oxohexan-2-yl]-1,2,3,4a,5,6,12,12a-octahydropyrano[3,2-a]xanthene-8,11-dione

1.2 Other means of identification

Product number -
Other names Cochliochinon B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:32450-26-3 SDS

32450-26-3Upstream product

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