324519-66-6

Basic information

• Product Name: 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)-
• Synonyms: 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)-;(2S,4E)-5-Chloro-2-(1-methylethyl)-4-pentenoic acid;Aliskiren inter-3;(2S,4E)-5-chloro-2-isopropylpent-4-enoic acid;(S,E)-5-chloro-2-isopropylpent-4-enoic acid;(E,2S)-5-Chloro-2-isopropyl-pent-4-enoic acid
• CAS NO: 324519-66-6
• Molecular Formula: C₈H₁₃ClO₂
• Molecular Weight: 176.64
• Product Categories: Drug Intermediates
• Mol File: 324519-66-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 266 ºC
• Flash Point: 114 ºC
• Appearance: /
• Density: 1.097
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)-(324519-66-6)
• EPA Substance Registry System: 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)-(324519-66-6)

Safety Data

• Hazardous Substances Data: 324519-66-6(Hazardous Substances Data)

Usage

General Description

4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)- is a chemical compound with the molecular formula C8H13ClO2. It is an organic compound classified as an unsaturated carboxylic acid and is commonly used in the synthesis of pharmaceuticals and agricultural chemicals. The (2S,4E)- designation in its chemical name indicates the stereochemistry of the molecule, specifically the configuration of its chiral centers. 4-Pentenoic acid, 5-chloro-2-(1-methylethyl)-, (2S,4E)- has potential applications in the pharmaceutical industry due to its structural characteristics and reactivity, making it a subject of interest in medicinal chemistry and drug development.

InChI:InChI=1/C8H13ClO2/c1-6(2)7(8(10)11)4-3-5-9/h3,5-7H,4H2,1-2H3,(H,10,11)/b5-3+/t7-/m0/s1

Upstream product

• 324519-67-7 (S,E)-ethyl 5-chloro-2-isopropylpent-4-enoate 
• 324519-70-2 C₁₈H₂₂ClNO₃ 
• 942220-52-2 C₆H₁₄N₂O₂*C₈H₁₃ClO₂ 

Downstream Products

• 387353-77-7 methyl (S)-(4E)-5-chloro-2-isopropyl-4-pentenoate 
• 324519-68-8 trans-(2S)-5-chloro-2-isopropyl-N,N-dimethyl-4-pentenamide 
• 387353-72-2 (2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid 
• 387353-70-0 (2S,7R,E)-ethyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate 
• 325740-70-3 (3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 
• 325154-26-5 (2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-N,N,8-trimethylnon-4-enamide 
• 393108-57-1 (3S,5S)-5-{(1R,3S)-1-bromo-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one 
• 324763-46-4 (3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one 

Relevant articles and documents

A aliskiren or its salt separation and analysis method

The invention relates to a separation analysis method using polysaccharide derivative-bonded and coated silica as a stationary phase and an organic solvent as a mobile phase for separation analysis of aliskiren and isomers thereof, effective separation of the aliskiren and isomers thereof can be realized, and the separation analysis method has the important meaning to the product quality control.

PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE (4E)-5- HALO-2-ALKYLPENT-4-ENOIC ACIDS AND THEIR ESTER DERIVATIVES

A process for the preparation of optically active (4E)-5-halo-2-alkylpent-4-enoic acids and their ester derivatives by a stereoselective synthesis which employs camphorsultam as chiral auxiliary is disclosed; in particular methyl (2S, 4E)-5-chloro-2-isopropylpent-4-enoate is prepared, which is a key intermediate in the manufacturing of the new anti-hypertension drug Aliskiren. Furthermore novel N-(5-halo-2-alkylpent-4-enoyl) camphorsultams are provided. A process for the hydrolysis of substituted N-acylcamphorsultams with strong acids is also provided.