32457-23-1

Basic information

• Product Name: 2,3-Dihydro-1H-inden-1-amine hydrochloride
• Synonyms: (S)-1-Aminoindane hydrochloride;(S)-1-Indanamine hydrochloride;Rasagiline interMediate;1H-Inden-1-aMine, 2,3-dihydro-, hydrochloride (1:1), (1S)-;(S)-(+)-1-Aminoindan HCl;1-Indanamine hydrochloride;(S)-(+)-1-Aminoindan hydrochloride;(S)-2,3-Dihydro-1H-inden-1-amine Hydrochloride,99%e.e.
• CAS NO: 32457-23-1
• Molecular Formula: C₉H₁₁N*ClH
• Molecular Weight: 170
• EINECS: 1312995-182-4
• Mol File: 32457-23-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2,3-Dihydro-1H-inden-1-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-1H-inden-1-amine hydrochloride(32457-23-1)
• EPA Substance Registry System: 2,3-Dihydro-1H-inden-1-amine hydrochloride(32457-23-1)

Safety Data

• Hazardous Substances Data: 32457-23-1(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-1H-inden-1-amine hydrochloride is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is an amine derivative with a hydrochloride salt group, making it water-soluble and easily accessible for experimental use. 2,3-Dihydro-1H-inden-1-amine hydrochloride has been studied for its potential applications in the development of new drugs and as a building block for the synthesis of various organic compounds. It has shown promising results in the field of medicinal chemistry, and its structure and properties make it a valuable tool for researchers in the pharmaceutical industry. Additionally, it has also been investigated for its potential biological activities and has shown potential as a potent biological response modifier.

Upstream product

• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 83-33-0 inden-1-one 
• 911372-45-7 (R_S)-N-(2,3-dihydroinden-1-ylidene)-2-methylpropane-2-sulfinamide 
• 911372-62-8 (R_S)-N-((S)-2,3-dihydro-1H-inden-1-yl)-2-methylpropane-2-sulfinamide 

Downstream Products

• 10277-74-4 (S)-1-Aminoindane 
• 905580-90-7 (1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-(hydroxymethyl)-cyclopentanol 

Relevant articles and documents

Dynamic power learning split preparation (S)- 1 - amino indane

The invention relates to a preparation method of optically pure (S)-1-aminoindane. The preparation method comprises steps as follows: 1-aminoindane is taken as a raw material, a solvent, Candida rugose lipase, an acyl donor L-(+)-O-acetyl mandelic acid and a racemization catalyst KT-02 are added to a high pressure kettle in proportion, hydrogen is introduced, all components react for a period of time, and then 1-aminoindane can be completely converted into an acetyl compound of (S)-1-aminoindane. A product is purified and subjected to acid hydrolysis and alkali free operation, (S)-1-aminoindane is obtained, and an ee value of a final product is larger than 99%. The preparation method has the characteristics that the operation is simple, the racemization catalyst is cheap and available, the raw material is completely utilized, the optical purity of the product is high and the like; the preparation method has great guidance and application value in the aspect of production and preparation of (S)-1-aminoindane.

Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines

A variety of N-tert-butanesulfinyl imines were reduced with NaBH 4 in THF containing 2% water to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By using the same sulfinyl imine starting materials and changing the reductant to L-Selectride, the stereoselectivity could be efficiently reversed to afford the opposite product diastereomer in high yield and selectivity.