324740-29-6

Basic information

• Product Name: 3-O-(tert-butyldiphenylsilyl)diosgenin
• Synonyms: 3-O-(tert-butyldiphenylsilyl)diosgenin
• CAS NO: 324740-29-6
• Molecular Weight: 653.033
• Mol File: 324740-29-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-O-(tert-butyldiphenylsilyl)diosgenin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-(tert-butyldiphenylsilyl)diosgenin(324740-29-6)
• EPA Substance Registry System: 3-O-(tert-butyldiphenylsilyl)diosgenin(324740-29-6)

Safety Data

• Hazardous Substances Data: 324740-29-6(Hazardous Substances Data)

Upstream product

• 512-04-9 diosgenin 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 14320-81-1 20-epi-verazine 
• 934535-36-1 (25R)-3β-tert-butyldiphenylsilyloxy-5,6-epoxy-spirostan-16α-ol 
• 324740-30-9 C₄₃H₆₀Br₂O₃Si 
• 637029-17-5 (22R,25R)-3β-O-tert-butyldiphenylsilyloxy-26-hydroxy-5-furosten 
• 126-17-0 solasodine 
• 1307870-98-9 C₄₃H₆₁N₃O₃Si 

Relevant articles and documents

Chemical intertransformations of diverse bisdesmosidic furostanol saponins

An effective synthetic route towards four types of bisdesmosidic furostanol saponin was developed and 36 derivatives were designed and synthesized for antitumor investigation. The chemical intertransformations of these furostanol structures were discussed

Stereoselective Synthesis of (-)-Verazine and Congeners via a Cascade Ring-Switching Process of Furostan-26-acid

An efficient synthetic strategy for three natural seco-type cholestane alkaloids isolated from the Veratrum plants, based on commercially available naturally occurring and abundant (-)-diosgenin (1), as exemplified in the concise asymmetric synthesis of (-)-verazine (4), (-)-veramiline (5) (proposed structure), and its 22-epimer, (-)-oblonginine (6), is presented. This work highlights the application of a cascade ring-switching process of (-)-diosgenin to achieve the E-ring opening and construction of chiral six-membered lactone challenges in seco-type cholestane alkaloid synthesis. This approach enables the synthesis of related natural and nature-like novel cholestane alkaloids, opening up opportunities for more extensive exploration of cholestane alkaloid biology.

An efficient and recyclable catalyst for the cleavage of tert-butyldiphenylsilyl ethers

An efficient, chemoselective, and environment-friendly method for the deprotection of tert-butyldiphenylsilyl ethers mediated by triflic acid supported on silica gel is reported. A wide range of tert-butyldiphenylsilyl ethers derived from carbohydrate and saponin residues can be smoothly cleaved in the presence of various types of other protecting groups in good to excellent yields in acetonitrile. This heterogeneous reaction does not require aqueous workup, and the supported catalyst can be readily recycled.