324741-62-0Relevant academic research and scientific papers
Nickel-Catalyzed Heteroarenes Cross Coupling via Tandem C-H/C-O Activation
Wang, Ting-Hsuan,Ambre, Ram,Wang, Qing,Lee, Wei-Chih,Wang, Pen-Cheng,Liu, Yuhua,Zhao, Lili,Ong, Tiow-Gan
, p. 11368 - 11376 (2018/11/23)
Inert aryl methyl ethers as coupling components via C-O activation have been established with a Ni catalyst for C-H activation of heteroarene. The key to simultaneous C-H/C-O bond activation is the use of sterically demanding o-tolylMgBr. The protocol is effective for a wide scope of substrates including naphthyl methyl ethers, anisoles, and a variety of other heteroarene derivatives. Detailed mechanistic studies indicated that the C-O cleavage is assisted via synergistic effect of nickel and Grignard reagent in this C-H/C-O reaction, which is supported by DFT calculation. At this stage, single-electron transfer can be ruled out as a main operative process for this tandem strategy.
Palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine
Huang, Chunhui,Giokaris, Alexandros,Gevorgyan, Vladimir
supporting information; experimental part, p. 1053 - 1054 (2011/12/05)
A direct palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine with aryl bromides has been developed. This reaction is quite general with respect to the aryl or hetaryl bromide.
