324753-65-3

Upstream product

• 324753-55-1 (S)-(+)-2-hydroxy-3-methylbutanal N,N-diphenylhydrazone 
• 324753-60-8 (S)-(+)-2-[(dimethyl)(vinyl)silyloxy]-3-methylbutanal N,N-diphenylhydrazone 
• 228716-82-3 (S)-2-(tert-butyldimethylsilanyloxy)-3-methylbutyric acid methyl ester 
• 136779-39-0 (S)-methyl 2-(tert-butyldimethylsilyloxy)-3-methylbutanal 

Downstream Products

• 324753-74-4 ((4R,5S)-5-Isopropyl-2,2-dimethyl-4-vinyl-oxazolidin-3-yl)-diphenyl-amine 
• 652156-83-7 (S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol 

Relevant academic research and scientific papers

Enhanced reactivity in radical cyclizations of hydrazones using the silicon-tethered 1-bromovinyl group

A silicon-tethered 1-bromovinyl group was shown to function as a radical precursor for tin-mediated vinyl additions to chiral α- or β-hydroxyhydrazone. In contrast to related thiyl-mediated methods, these vinyl bromides were not limited to the 5-exo cycli

A Silicon Tether Approach for Addition of Functionalized Radicals to Chiral α-Hydroxyhydrazones: Diastereoselective Additions of Hydroxymethyl and Vinyl Synthons

Stereocontrolled additions of hydroxymethyl and vinyl groups to chiral α-hydroxyhydrazones can be achieved by radical cyclizations using bromomethyl or vinyl radical precursors tethered via a temporary silicon connection. Tin-mediated 5-exo radical cycliz

Diastereoselective vinyl addition to chiral hydrazones via tandem thiyl radical addition and silicon-tethered cyclization

(equation presented) A diastereoselective method for addition of a vinyl group to α-hydroxy hydrazones under neutral tin-free radical cyclization conditions, leading to substituted vinylglycinols, is presented. Tandem thiyl radical addition/cyclization up