32480-08-3

Usage

Uses

Used in Food and Beverage Industry:
3,7,11-Trimethyl-(E)-6,10-dodecadienal is used as a flavoring agent for its distinct green, floral, and fruity aroma, enhancing the taste and aroma of various food and beverage products.
Used in Insect Communication:
In certain insects, tridecadienal serves as a pheromone component, acting as a chemical signal for mating and communication. It plays a crucial role in the reproductive and social behavior of these species.
Used in Pest Control:
3,7,11-Trimethyl-(E)-6,10-dodecadienal has been studied for its potential use as a natural pesticide due to its insecticidal properties. It can be utilized as an eco-friendly alternative to synthetic pesticides, helping control pest populations in agricultural settings.

Upstream product

• 106-28-5 Farnesol 
• 19317-11-4 farnesal 

Relevant academic research and scientific papers

Inactivation of protein farnesyltransferase by active-site-targeted dicarbonyl compounds

Upon farnesylation by protein farnesyltransferase (FTase), key proteins become compartmentalized in cells. For example, cell membrane localization is essential for the mitogenic role of mutant Ras protein, which acts as a switch for cancer cell proliferation. We report that α-dicarbonyl compounds derived from the isoprenoid skeleton or other hydrophobic groups potently obstruct farnesylation of a Ras model peptide by human recombinant FTase in vitro. A geranyl-derived isoprenoid diketone, 5,9-dimethyl-8-decene-2,3-dione, at 17 μM caused a 62% reduction in FTase activity after 30 minutes. A farnesyl-derived isoprenoid diketone, 5,9,13-trimethyl-8,12-tetradecadiene-2,3-dione, at 93 μM caused a 94% reduction after 30 minutes. Other dicarbonyl compounds found to be effective against FTase in vitro were (±)-6-(camphorquinone-10-sulfonamido)-hexanoic acid, 4,4′-biphenyldiglyoxaldehyde, dehydroascorbic acid 6-palmitate, 2-oxododecanal, and phenylglyoxal. Higher concentrations of the α-dicarbonyl compound resulted in more rapid and more extensive inactivation. These findings demonstrate that α-dicarbonyl compounds targeted to FTase interfere with protein farnesylation in vitro and may lead to derivatives that have utility as chemotherapeutic agents.