32515-07-4

Basic information

• Product Name: 1-BENZYL-4-PHENYL-1H-1,2,3-TRIAZOL-5-AMINE
• Synonyms: 1-BENZYL-4-PHENYL-1H-1,2,3-TRIAZOL-5-AMINE;3-BENZYL-5-PHENYL-3H-[1,2,3]-TRIAZOL-4-YLAMINE;1-Benzyl-4-phenyl-1H-1,2,3-triazol-5-amine 95%
• CAS NO: 32515-07-4
• Molecular Formula: C₁₅H₁₄N₄
• Molecular Weight: 250.3
• Mol File: 32515-07-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 158
• Boiling Point: 479.2 °C at 760 mmHg
• Flash Point: 243.6 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 2.42E-09mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: 1-BENZYL-4-PHENYL-1H-1,2,3-TRIAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-4-PHENYL-1H-1,2,3-TRIAZOL-5-AMINE(32515-07-4)
• EPA Substance Registry System: 1-BENZYL-4-PHENYL-1H-1,2,3-TRIAZOL-5-AMINE(32515-07-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 32515-07-4(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-phenyl-1H-1,2,3-triazol-5-amine is a chemical compound with the molecular formula C16H15N5. It is a triazole derivative with a benzyl and phenyl substituent, and an amine functional group. 1-BENZYL-4-PHENYL-1H-1,2,3-TRIAZOL-5-AMINE has potential biological activity and is often used in medicinal chemistry and drug development. Triazoles are known for their diverse pharmacological properties and have been explored for their antifungal, antibacterial, and anticancer activities. The unique structure of 1-benzyl-4-phenyl-1H-1,2,3-triazol-5-amine makes it an interesting target for further research and exploration in the field of medicinal chemistry.

InChI:InChI=1/C15H14N4/c16-15-14(13-9-5-2-6-10-13)17-18-19(15)11-12-7-3-1-4-8-12/h1-10H,11,16H2

Upstream product

• 140-29-4 phenylacetonitrile 
• 622-79-7 benzyl azide 
• 108841-95-8 benzyl-(5-phenyl-1H-[1,2,3]triazol-4-yl)-amine 
• 107-21-1 ethylene glycol 

Downstream Products

• 108841-95-8 benzyl-(5-phenyl-1H-[1,2,3]triazol-4-yl)-amine 

Relevant articles and documents

One-Pot Synthesis of 5-Amino-1,2,3-triazole Derivatives via Dipolar Azide?Nitrile Cycloaddition and Dimroth Rearrangement under Solvent-Free Conditions

An efficient one-pot methodology for the preparation of 5-amino-1,2,3-triazole derivatives based on the combination of dipolar azide?nitrile cycloaddition with Dimroth rearrangement under solvent-free conditions has been developed.

An Improved Procedure for the Preparation of 1-Benzyl-1H-1,2,3-triazoles from Benzyl Azides.

A procedure for the preparation of substituted 1-benzyl-1H-1,2,3-triazoles from benzyl azides under very mild conditions is described.The method provides improved yields and extends the scope of the Dimroth Reaction to other types of active methylene compound to those previously used.Benzyl azides react with active methylene compounds in dimethyl sulphoxide catalysed by potassium carbonate at 35-40 deg C to give 1H-1,2,3-triazoles usually in good yield.Acetonitrile derivatives gave 5-amino-1H-1,2,3-triazoles whereas diethyl malonate gave 5-hydroxy-1H-1,2,3-triazoles. 1H-1,2,3-Triazole-4-carboxylate esters and 1H-1,2,3-triazole-4-ketones were obtained from ethyl acetoacetate and β-diketones respectively.Benzyl methyl ketone reacted to give 5-methyl-4-phenyl-1H-1,2,3-triazole, but acetone and acetophenone failed to react.Other active methylene compounds which did not react under these reaction conditions included ethyl cyanoacetate, ethyl fluoroacetate and ethyl nitroacetate.