325153-00-2

Usage

Uses

Used in Scientific Research:
Benzeneethanol, beta-amino-3-methoxy(9CI) is used as a research chemical in various scientific studies and experiments. Its unique structure and properties make it a valuable compound for exploring new chemical reactions and syntheses.
Used in Organic Synthesis:
As an organic building block, Benzeneethanol, beta-amino-3-methoxy(9CI) is used in the synthesis of various organic compounds. Its presence in phenylpropane derivatives allows for the creation of a wide range of chemical structures with potential applications in different industries.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, the compound's potential use in the pharmaceutical industry can be inferred due to its role as an organic building block. It may be utilized in the development of new drugs or as an intermediate in the synthesis of existing medications.
Used in Chemical Industry:
Benzeneethanol, beta-amino-3-methoxy(9CI) may also find applications in the chemical industry, where it can be used as a precursor or intermediate in the production of various chemical products, including specialty chemicals, dyes, and other organic compounds.

Upstream product

• 87428-52-2 2-hydroxy-3'-methoxyacetophenone 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 5020-41-7 2-(3-methoxyphenyl)-ethanol 

Relevant academic research and scientific papers

BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR

The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

Catalytic β C-H amination: Via an imidate radical relay

The first catalytic strategy to harness imidate radicals for C-H functionalization has been developed. This iodine-catalyzed approach enables β C-H amination of alcohols by an imidate-mediated radical relay. In contrast to our first-generation, (super)stoichiometric protocol, this catalytic method enables faster and more efficient reactivity. Furthermore, lower oxidant concentration affords broader functional group tolerance, including alkenes, alkynes, alcohols, carbonyls, and heteroarenes. Mechanistic experiments interrogating the electronic nature of the key 1,5 H-atom transfer event are included, as well as probes for chemo-, regio-, and stereo-selectivity.

Directed β C-H Amination of Alcohols via Radical Relay Chaperones

A radical-mediated strategy for β C-H amination of alcohols has been developed. This approach employs a radical relay chaperone, which serves as a traceless director that facilitates selective C-H functionalization via 1,5-hydrogen atom transfer (HAT) and enables net incorporation of ammonia at the β carbon of alcohols. The chaperones presented herein enable direct access to imidate radicals, allowing their first use for H atom abstraction. A streamlined protocol enables rapid conversion of alcohols to their β-amino analogs (via in situ conversion of alcohols to imidates, directed C-H amination, and hydrolysis to NH2). Mechanistic experiments indicate HAT is rate-limiting, whereas intramolecular amination is product- and stereo-determining.

Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation

(Chemical Equation Presented) Formal aromatic C-H insertion of rhodium(II) carbenoid was intensively investigated to develop a new methodology and probe its mechanism. Contrasting with the previously proposed direct C-H insertion, the mechanism was revealed to be electrophilic aromatic substitution, which was supported by substituent effects on the aromatic ring and a secondary deuterium kinetic isotope effect. Various isoquinolinones were synthesized intramolecularly via six-membered ring formation with high regioand diastereoselectivity, while averting the common Buchner-type reaction. Intermolecularly, dirhodium catalyzed formal aromatic C-H insertion on electron-rich aromatics was also achieved.