325172-40-5Relevant academic research and scientific papers
Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation
Choi, Sei-hyun,Franklin, Joseph Livy,Huang, Teng-Yi,Hung, Shang-Cheng,Jeon, Byung-sun,Kim, Namho,Liu, Hung-wen,Ruszczycky, Mark W.
supporting information, (2021/11/30)
Biosynthesis of spinosyn A in Saccharopolyspora spinosa involves a 1,4-dehydration followed by an intramolecular [4 + 2]-cycloaddition catalyzed by SpnM and SpnF, respectively. The cycloaddition also takes place in the absence of SpnF leading to questions
Total Synthesis of (-)-Citreoisocoumarin, (-)-Citreoisocoumarinol, (-)-12-epi-Citreoisocoumarinol, and (-)-Mucorisocoumarins A and B Using a Gold(I)-Catalyzed Cyclization Strategy
Mallampudi, N. Arjunreddy,Choudhury, Utkal Mani,Mohapatra, Debendra K.
, p. 4122 - 4129 (2020/04/10)
A unified and concise first asymmetric total synthesis of (-)-citreoisocoumarin (2), (-)-citreoisocoumarinol (3), 12-epi-citreoisocoumarinol (4), and (-)-mucorisocoumarins A (5) and B (6) have been accomplished from the common intermediate (-)-6-O-methyl-
Stereoselective synthesis of dendrodolide-L
Bujaranipalli, Sheshurao,Das, Saibal
, p. 254 - 260 (2017/03/01)
An efficient stereoselective total synthesis of 12-membered macrolide dendrodolide L has been achieved. The key reactions involved are Keck asymmetric allylation, Jacobsen's hydrolytic kinetic resolution, Sharpless asymmetric epoxidation, Mitsunobu reaction and ring-closing metathesis reaction.
Stereoselective synthesis of 1,3-anti diols by an Ipc-mediated domino aldol-coupling/reduction sequence
Dieckmann, Michael,Menche, Dirk
, p. 228 - 231 (2013/03/28)
A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate β-hydrox
Iodocyclization and prins-type macrocyclization: An efficient formal synthesis of leucascandrolide A
Yadav,Pattanayak, Manas R.,Das, Pragna P.,Mohapatra, Debendra K.
, p. 1710 - 1713 (2011/06/17)
The formal total synthesis of leucascandrolide A has been achieved in 20 steps from a known epoxide with an overall yield of 11.5% following a recently developed strategy for the construction of trans-2,6-disubstituted-3,4- dihydropyrans and a Lewis acid
Asymmetric total synthesis of rugulactone, an α-pyrone from Cryptocarya rugulosa
Allais, Florent,Aouhansou, Mahoulo,Majira, Amel,Ducrot, Paul-Henri
experimental part, p. 2787 - 2793 (2010/10/18)
A total asymmetric synthesis of rugulactone, a naturally occuring -pyrone isolated from Cryptocarya rugulosa, is reported. The synthesis involved a cross-metathesis coupling reaction to construct the internal E-olefin group, a Still-Gennari olefination to
Short diastereoselective synthesis of the C1-C13 (AB Spiroacetal) and C17-C28 fragments (CD spiroacetal) of spongistatin 1 and 2 through double chain-elongation reactions
Flowers, Christopher L.,Vogel, Pierre
supporting information; experimental part, p. 14074 - 14082 (2011/02/23)
A unique and practical synthetic sequence for rapid access to polyketides and to further the spiroacetals derived from them, which utilizes a bidirectional Hosomi-Sakurai allylation approach around key allylsilanes in the synthesis of the AB and CD ring s
Revision of the absolute configuration of salicylihalamide A through asymmetric total synthesis
Wu, Yusheng,Esser, Lothar,De Brabander, Jef K.
, p. 4308 - 4310 (2007/10/03)
A highly E-selective ring-closing metathesis is the key to building the macrocyclic salicylate core of (+)-salicylihalamide A (1). The synthesis results in a reassignment of the absolute configuration of natural (-)-salicylihalamide A (2), a structurally
