32531-67-2Relevant academic research and scientific papers
An unusual carbon-carbon bond scission reaction with molecular oxygen under mild conditions; formation of piperidines from 1-azabicyclo[2.2.2]octanes
Norris, Timothy,Santafianos, Dinos,Bordner, Jon
, p. 3679 - 3684 (2007/10/03)
Molecular oxygen reacts with 2-(1-phenylethyl)- and 2-benzhydryl-3-alkylimino-1-azabicyclo[2.2.2]-octanes 1-7 in neutral solution at room temperature to form 1-acylpiperidine-4-carboxylic acid N-alkylamides 8-14. During the transformation two new carbonyl bonds are formed and a carbon-carbon bond is cleaved. The transformation is quite general provided the 2-substituent of the imine is of sufficient steric bulk, such as the 2-(1-phenylethyl) or 2-benzhydryl groups. No reaction is observed in the absence of a 2-substituent, as in the case of imine 15.
Quinuclidine chemistry. 4. Diuretic properties of cis 3 amino 2 benzhydrylquinuclidine
Warawa,Mueller,Fleming
, p. 587 - 593 (2007/10/05)
A number of 3 amino 2 benzhydrylquinuclidines were tested for diuretic activity in both rats and dogs. The Schiff base formed from 2 benzhydryl 3 quinuclidinone and benzylamine was reduced with NaBH4 to a mixture of isomers, the cis isomer bein
