32539-74-5

Upstream product

• 533937-68-7 5-phenyl-isothiazole-4-carbonitrile 
• 32551-25-0 5-phenyl-isothiazole-4-carboxylic acid methyl ester 
• 60027-35-2 4-phenyl-1,3,2-oxathiazolylium-5-olate 
• 32585-80-1 5-phenyl-isothiazole-3,4-dicarboxylic acid dimethyl ester 
• 32539-73-4 5-phenyl-isothiazole-3,4-dicarboxylic acid 

Downstream Products

• 18160-83-3 5-bromo-3-phenyl-isothiazole-4-carboxylic acid 
• 1258841-15-4 (octahydro-quinolin-1-yl)-(5-phenyl-isothiazol-4-yl)-methanone 
• 32551-25-0 5-phenyl-isothiazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

AMIDO-ISOTHIAZOLE COMPOUNDS AND THEIR USE AS INHIBITORS OF 11BETA-HSD1 FOR THE TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole compounds that, inter alia, inhibit 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.