32544-85-7Relevant academic research and scientific papers
A domino amino-lactonisation of arylidene pyruvic acids (APAs) by amines in aqueous media
Shiri, Morteza,Heravi, Majid M.,Soleymanifard, Bita,Kruger, Hendrik G.,Zolfigol, Mohammad Ali
, p. 3257 - 3263 (2013/04/23)
The aqueous reaction of arylidene pyruvic acids (APAs) with arylamines or urea under refluxing conditions leading to the formation of 3-(amino)-5-aryl- furan-2(5H)-one, without catalyst, is described. Also (E)-4-(4-chlorophenyl)-2- oxobut-3-enoic acid reacts with 1,2-phenylenediamine to form (E)-3-(4-chlorostyryl)quinoxalin-2(1H)-one under the same conditions. Excellent yields were observed after filtration of the product and washing with brine solution.
