32545-71-4Relevant academic research and scientific papers
Hree-component reaction of benzylamines, diethyl phosphite and triethyl orthoformate: Dependence of the reaction course on the structural features of the substrates and reaction conditions
Miszczyk, Atrycja,Turowska-Tyrk, Ilona,Kafarski, Pawel,Chmielewska, Ewa
, (2017/03/24)
The reaction between benzyl amines, triethyl orthoformate, and diethyl phosphite affords either bisphosphonic (compound 1) or N-benzylaminobenzylphosphonic (compound 2) acid depending on the reaction conditions. The final output of the reaction can be manipulated by the choice of reaction conditions, particularly the molar ratio of substrates.
The preparation of N-substituted aminomethylidenebisphosphonates and their tetraalkyl esters via reaction of isonitriles with trialkyl phosphites and hydrogen chloride. Part 1
Goldeman, Waldemar,Kluczyński, Artur,Soroka, Miros?aw
, p. 5290 - 5292 (2012/11/13)
The reaction of isonitriles with trialkyl phosphites in the presence of hydrogen chloride gives tetraalkyl N-substituted aminomethylidenebisphosphonates via N-methylideneaminium (isonitrilium) salts. Hydrolysis or dealkylation of these tetraalkyl esters gives N-substituted aminomethylidenebisphosphonic acids in high yields.
1-Aminoalkane-1,1-diphosphonic acids and their salts
-
, (2008/06/13)
A process for the production of 1-aminoalkane-1,1-diphosphonates of the formula SPC1 Wherein R1 is a member selected from the group consisting of hydrogen, lower alkyl and phenyl, R2 and R 3 are members selected from the group consisting of hydrogen, alkyl having 1 to 22 carbon atoms, cycloalkyl having 5 to 6 carbon atoms, phenyl, alkylphenyl having 7 to 18 carbon atoms, phenylalkyl having 7 to 18 carbon atoms and together with the nitrogen atom, piperidino, pyrrolidino and morpholino, and X is a member selected from the group consisting of hydrogen, alkali metal, ammonium, pyridinium, guanidinium and mono-, di-, and tri-lower-alkanol-ammonium with the proviso that at least one of R1, R2 and R3 is other than hydrogen, which consists essentially in reacting a phosphorus trihalide selected from the group consisting of phosphosus trichloride and phosphorus tribromide with a monocarboxylic acid amide of the formula SPC2wherein the molecular weight of said carboxylic acid amide is over 46 and R1, R2 and R 3 have the above assigned meanings, at a temperature of from 0° to 75°C, subjecting the resultant reaction product to hydrolysis, and recovering said 1-aminoalkane-1,1-diphosphonates. The 1-aminoalkane-1,1-diphosphonates, some of which are novel, are capable of forming complexes with heavy metals.
