325457-63-4

Usage

Uses

Used in Organic Synthesis:
[1,1'-Biphenyl]-3-carbonitrile, 3'-(broMoMethyl)is used as an intermediate in the synthesis of various organic compounds due to its unique functional groups, which can be further modified or reacted to produce a range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, [1,1'-Biphenyl]-3-carbonitrile, 3'-(broMoMethyl)is used as a building block for the development of new drugs. Its specific functional groups can be exploited to create molecules with desired biological activities, potentially leading to the discovery of novel therapeutic agents.
Used in Materials Science:
[1,1'-Biphenyl]-3-carbonitrile, 3'-(broMoMethyl)may also find applications in materials science, where its unique chemical structure could be utilized to develop new materials with specific properties, such as improved conductivity, strength, or stability.

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 150255-96-2 (3‐cyanophenyl)boronic acid 
• 591-17-3 meta-bromotoluene 
• 247183-18-2 3-(3-cyanophenyl)-1-methylbenzene 

Downstream Products

• 544694-81-7 4-{4-[(3'-carbamimidoyl-biphenyl-3-ylmethyl)-ethoxycarbonylmethanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester 
• 364614-53-9 ((3'-carbamimidoyl-biphenyl-3-ylmethyl)-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-sulfamoyl)-acetic acid ethyl ester 
• 544694-97-5 4-[4-(3'-carbamimidoyl-biphenyl-3-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yloxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 544694-60-2 4-{4-[(3'-carbamimidoyl-biphenyl-3-ylmethyl)-methanesulfonyl-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester 
• 364614-38-0 3'-[({4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-phenyl}-methanesulfonyl-amino)-methyl]-biphenyl-3-carboxamidine 
• 400748-29-0 3'-formyl-[1,1'-biphenyl]-3-carbonitrile 

Relevant academic research and scientific papers

Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors

A series of benzoxazinone derivatives was designed and synthesized as factor Xa inhibitors. We demonstrated that the naphthyl moiety in the aniline-based compounds 1 and 2 can be replaced with benzene-fused heterobicycles and biaryls to give factor Xa inh

BIPHENYL DERIVATIVES

Novel compounds of the formula I in which X, R 1, R 2, R 3, R 4 and R 5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.

Benzimidazole-Based fXa inhibitors with improved thrombin and trypsin selectivity

Optimization of the benzimidazole-based fXa inhibitors for selectivity versus thrombin and trypsin was achieved by substitution on the benzimidazole ring and replacement of the naphthylamidine group. Substitution of a nitro group at the 4-position on the benzimidazole improves both potency against fXa and selectivity versus thrombin. Alternatively, replacement of the naphthylamidine with either a biphenylamidine or propenylbenzamidine not only improves fXa potency and selectivity versus thrombin, but selectivity versus trypsin as well.

Benzenamine derivatives as anti-coagulants

This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R1, R2, R3, R4, R5and R6are defined herein. These compounds are useful as anti-coagulants.