325457-67-8

Basic information

• Product Name: Benzaldehyde, 5-bromo-2-[(4-methoxyphenyl)methoxy]-
• CAS NO: 325457-67-8
• Molecular Formula: C15H13BrO3
• Molecular Weight: 321.17
• Mol File: 325457-67-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 5-bromo-2-[(4-methoxyphenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 5-bromo-2-[(4-methoxyphenyl)methoxy]-(325457-67-8)
• EPA Substance Registry System: Benzaldehyde, 5-bromo-2-[(4-methoxyphenyl)methoxy]-(325457-67-8)

Safety Data

• Hazardous Substances Data: 325457-67-8(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 1761-61-1 5-bromosalicyclaldehyde 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 632625-49-1 1-[5-bromo-2-(4-methoxybenzyloxy)phenyl]-pentane-1,4-dione 
• 632622-84-5 5-{2-[5-bromo-2-(3,4-dichlorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-nicotinic acid 
• 632622-85-6 5-{2-[5-bromo-2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-nicotinic acid 
• 632625-87-7 5-{2-[5-bromo-2-(4-methoxybenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-nicotinic acid ethyl ester 
• 632622-83-4 5-{2-[5-bromo-2-(4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-nicotinic acid 
• 632621-90-0 5-{2-[5-bromo-2-(4-methoxybenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-nicotinic acid 
• 632622-82-3 5-{2-[5-bromo-2-(4-chlorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-nicotinic acid 

Relevant articles and documents

GPR35 MODULATORS

Described herein are GPR35 modulators and methods of using these compounds in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives

High throughput screening (HTS) led to the identification of the guanylhydrazone of 2-(4-chlorobenzyloxy)-5-bromobenzaldehyde as a CCR5 receptor antagonist. Initial modifications of the guanylhydrazone series indicated that substitution of the benzyl group at the para-position was well tolerated. Substitution at the 5-position of the central phenyl ring was critical for potency. Replacement of the guanylhydrazone group led to the discovery of a novel series of CCR5 antagonists.

PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine, in particular their use in the treatment of prostaglandin mediated diseases such as pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.