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Usage

Uses

1. Used in Cellular Research:
1-Oleoyl lysophosphatidic acid sodium salt is used as a cell growth stimulator for various cell types, including fibroblasts, vascular smooth muscle cells, endothelial cells, and keratinocytes. It acts as a proliferative and anti-apoptotic factor, promoting cell survival and growth.
2. Used in Signal Transduction Studies:
1-Oleoyl lysophosphatidic acid sodium salt is used as a signaling molecule in the study of LPA receptor-mediated signal transduction pathways. It helps researchers understand the role of LPA receptors in cellular processes and their potential as therapeutic targets.
3. Used in Neurobiology Research:
1-Oleoyl lysophosphatidic acid sodium salt is used as a modulator of axonal outgrowth in cortical progenitors. LPA-primed astrocytes induce axonal outgrowth, which is essential for understanding the development and maintenance of neural connections.
4. Used in Cancer Research:
1-Oleoyl lysophosphatidic acid sodium salt is used to induce cell migration in both cancerous and non-cancerous cells. This property makes it a valuable tool for studying the mechanisms underlying cell migration and invasion in cancer progression.
5. Used in Pharmacology:
1-Oleoyl lysophosphatidic acid sodium salt is used to study its effects on endothelial cell physiology, which are similar to those of sphingosine 1-phosphate. It does not induce angiogenesis but has significant effects on endothelial cell function.
6. Used in Ion Channel Research:
1-Oleoyl lysophosphatidic acid sodium salt is used to potentiate acetylcholine receptor currents through G-protein-mediated activation of Ca2+-dependent/independent protein kinase C. This application helps researchers understand the role of LPA in ion channel regulation and its potential implications in various diseases.

in vitro

lpa could mediate signal transduction via edg/lpa receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. additionally, lpa was found to elicit upregulation of vegf, leading to an indirect influence on initiation and progression of malignancies. lpa could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor [1].

in vivo

lpa was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the lpa receptor 1 and 3 antagonists. lpa also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of lpa receptor 1 or 3 [1].

References

1) Moolenaar?et al. (1995),?Lysophosphatidic acid, a multifunctional phospholipid messenger; J. Biol. Chem.,?270?12949 2) Levine?et al. (1997),?Lysophosphatidic acid; a novel growth and survival factor for renal proximal tubular cells; Am. J. Physiol.,?273?F575 3) Goetzl and An (1998),?Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate; FASEB J.,?12?1589 4) Spohr?et al. (2014),?LPA-primed astrocytes induce axonal outgrowth of cortical progenitors by activating PKA signaling pathways and modulating extracellular matrix proteins; Front Cell Neurosci.,?8?296