32548-16-6

Basic information

• Product Name: 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid
• Synonyms: 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid
• CAS NO: 32548-16-6
• Molecular Weight: 363.434
• Mol File: 32548-16-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid(32548-16-6)
• EPA Substance Registry System: 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid(32548-16-6)

Safety Data

• Hazardous Substances Data: 32548-16-6(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 
• 28395-03-1 Bumetanide 
• 200423-20-7 4-Chloro-3-hydroxysulfinylbenzoic acid 
• 1431505-00-8 methyl 3-(butylamino)-5-(methylsulfonyl)-4-phenoxybenzoate 
• 1431504-99-2 methyl 3-amino-5-(methylsulfonyl)-4-phenoxybenzoate 
• 1431504-98-1 methyl 3-(methylsulfonyl)-5-nitro-4-phenoxybenzoate 
• 32548-14-4 3-(methylsulfonyl)-5-nitro-4-phenoxybenzoic acid 
• 32548-10-0 3-methylsulfonyl-4-chloro-5-nitrobenzoic acid 
• 51522-07-7 3-methylsulphonyl-4-chlorobenzoic acid 
• 2494-79-3 4-chloro-3-(chlorosulfonyl)benzoic acid 

Downstream Products

• 1431501-23-3 N,N-dibutyl-3-(methylsulfonyl)-5-morpholino-2-phenoxyaniline 
• 1431501-27-7 3-(dibutylamino)-N,5-bis(methylsulfonyl)-4-phenoxybenzamide 
• 1431501-31-3 3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzoic acid sodium salt 
• 1431501-01-7 3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxybenzamide 
• 1431501-02-8 (3-(dibutylamino)-5-(methylsulfonyl)-4-phenoxyphenyl)(4-morpholinyl)methanone 

Relevant articles and documents

NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization

Herein we describe the development and application of a method for the mild, late-stage conversion of primary sulfonamides to several other other functional groups. These reactions occur via initial reductive deamination of sulfonamides to sulfinates via an NHC-catalyzed reaction of transiently formed N-sulfonylimines. The method described here is tolerant of nearly all common functional groups, as exemplified by the late-stage derivatization of several complex pharmaceutical compounds. On the basis of the prevalence of sulfonamide-containing drugs and building blocks, we have developed a method to enable sulfonamides to be applied as versatile synthetic handles for synthetic chemsitry.