32549-33-0

Usage

Uses

Used in Pharmaceutical Applications:
1-(4-CHLORO-PHENYL)-IMIDAZOLIDINE-2,4-DIONE is used as a pharmaceutical compound for its potential biological activities. Imidazolidine-2,4-dione derivatives, including 1-(4-CHLORO-PHENYL)-IMIDAZOLIDINE-2,4-DIONE, have been studied for their anticonvulsant, hypnotic, and sedative properties, making them promising candidates for the development of new medications to treat various conditions.
Used in Material Science Applications:
In the field of materials science, 1-(4-CHLORO-PHENYL)-IMIDAZOLIDINE-2,4-DIONE is used as a building block for the synthesis of novel materials. Imidazolidine-2,4-dione derivatives have been studied for their potential use in creating new materials with unique properties, which could have applications in various industries, such as electronics, automotive, and aerospace.

InChI:InChI=1/C9H7ClN2O2/c10-6-1-3-7(4-2-6)12-5-8(13)11-9(12)14/h1-4H,5H2,(H,11,13,14)

Upstream product

• 6092-47-3 ethyl (chloroacetyl)carbamate 
• 106-47-8 4-chloro-aniline 
• 1345028-87-6 C₁₀H₉ClN₂O₂ 
• 13014-48-7 4-chlorobenzoyl cyanide 
• 79-11-8 chloroacetic acid 
• 57-13-6 urea 

Downstream Products

• 188116-07-6 Imepitoin 
• 1317242-27-5 1-(4-chlorophenyl)-5-(thiiran-2-ylmethyl)imidazolidine-2,4-dione 
• 1317242-25-3 1-(4-chlorophenyl)-5-(oxiran-2-ylmethyl)imidazolidine-2,4-dione 
• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 1314745-27-1 1-(4-chlorophenyl)-2,4-dichloro-1H-imidazole-5-carbaldehyde 
• 1314745-47-5 2-({[2,4-dichloro-1-(4-chlorophenyl)-1H-imidazol-5-yl]methylene}amino)ethanol 
• 1240969-74-7 2-piperidinyl-1-(4-chlorophenyl)-4-chloro-1H-imidazole-5-carbaldehyde 
• 1314745-42-0 2-isopentoxy-1-(4-chlorophenyl)-4-chloro-1H-imidazole-5-carbaldehyde 
• 1314745-35-1 2-azido-1-(4-chlorophenyl)-4-chloro-1H-imidazole-5-carbaldehyde 

Relevant academic research and scientific papers

Preparation method for D, L-phenylglycine and analogue thereof

The invention provides a preparation method for D, L-phenylglycine and an analogue thereof. According to the method, benzaldehyde, an analogue thereof and hydrocyanic acid are adopted as raw materials and subjected to cyanidation reaction, and then 2-hydroxy-benzyl cyanide or 2-hydroxy-benzyl cyanide analogue (cyanohydrin for short) is generated. Cyanohydrin reacts with carbon dioxide and the aqueous solution of ammonia, and then 5-phenyl-hydantoin and an analogue thereof (hydantoin for short) are generated. hydantoin is successively subjected to steam stripping, alkaline hydrolysis, steam stripping, decolorization, neutralization, crystallization, washing, centrifuging, drying and the like to obtain D, L-phenylglycine and the analogue thereof. Compared with the prior art, the preparation method for D, L-phenylglycine and the analogue thereof can significantly and effectively reduce the pollution, and fewer inorganic salt by-products are generated. Meanwhile, the prepared D, L-phenylglycine and the analogue thereof are high in product yield and high in purity. Counted in benzaldehyde and the analogue thereof, the yield of D, L-phenylglycine and the analogue thereof is larger than or equal to 96%, and the product purity is larger than or equal to 99%. Meanwhile, the process flow is simple and feasible, so that the method is worthy of market popularization and application.

Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions

Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis-hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. Single crystal structures of some of the representative compounds are also reported.

Aryloxypropanolamine derivatives, pharmaceutical compositions and adrenegic thereof

Compounds having general formula I STR1 wherein R1 is hydrogen, lower alkyl, lower alkoxy, alkyl enoxy, halogen, cyano, carboxyamido or ureido group optionally separated from the phenyl ring by a methylene or ethylene bridge; R2 is hydrogen, halogen, lower alkyl or alkoxy; R3 is hydrogen, halogen, lower alkyl, lower alkoxy or R2 and R3, taken together, are a methylendioxy group; R4 is hydrogen or lower alkyl, endowed with remarkable cardioselective β-adrenolytic properties, are described. The process for their preparation and pharmaceutical compositions containing them are also described.